MABF390

Anti-CD152 (CTLA-4) Antibody (mouse), PE, clone UC10-4F10-11

clone UC10-4F10-11, 0.2 mg/mL, from hamster(Armenian)

• Synonym(e): Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: hamster (Armenian)
• Qualitätsniveau: 100
• Konjugat: PE
• Antikörperform: purified antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: UC10-4F10-11, monoclonal
• Speziesreaktivität: mouse
• Konzentration: 0.2 mg/mL
• Methode(n): flow cytometry: suitable
• Isotyp: IgG
• UniProt-Hinterlegungsnummer: P09793
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: mouse ... Ctla4(12477)

Beschreibung

Allgemeine Beschreibung

The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.

Immunogen

Immunogen information for this antibody is proprietary information.

Anwendung

Research Category
Entzündung & Immunologie

This armenian hamster monoclonal antibody Anti-CD152 (CTLA-4) (mouse), PE & clone UC10-4F10-11 validated for use in Flow Cytometry for the detection of CD152 (CTLA-4).

Qualität

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.06 µg of this antibody detected CD152 (CTLA-4) in one million C57Bl/6 splenocytes.

Physikalische Form

Size Exclusion Chromatography

Purified Armenian Hamster Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.

Lagerung und Haltbarkeit

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable