MABD19

Anti-DMP-1 (CT) Antibody, clone 8G10.3

clone 8G10.3, from mouse

• Synonym(e): Dentin matrix acidic phosphoprotein 1, DMP-1, Dentin matrix protein 1, AG1
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 8G10.3, monoclonal
• Speziesreaktivität: human
• Speziesreaktivität (Voraussage durch Homologie): mouse (based on 100% sequence homology), rat (based on 100% sequence homology)
• Methode(n): dot blot: suitable; immunohistochemistry: suitable
• Isotyp: IgG1κ
• NCBI-Hinterlegungsnummer: NP_987089
• UniProt-Hinterlegungsnummer: P98193
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... DMP1(1758)

Beschreibung

Allgemeine Beschreibung

Dentin matrix protein 1, also known as DMP-1, is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in DMP-1 are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia.

Spezifität

This antibody detects the C-Terminus of DMP-1.

Immunogen

57 kDa fragments isolated from rat bone

Epitope: C-terminus

Anwendung

Research Category
Stammzellforschung

Research Sub Category
Osteobiologie

Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in rat mandibular sections. (Baba, O., et al. (2004). Matrix Biology. 23:371–379.)

Dot Blot Analysis: A representative lot was used by an independent laboratory in DB. (Baba, O., et al. (2004). Matrix Biology. 23:371–379.)

This Anti-DMP-1 (C-terminus) Antibody, clone 8G10.3 is validated for use in IH, DB for the detection of DMP-1 (C-terminus).

Qualität

Evaluated by Immunohistochemistry in human tooth sections.

Immunohistochemistry Analysis: 1:50-1:250 dilution of this antibody detected DMP-1 in human tooth sections.

Zielbeschreibung

53 kDa calculated

Physikalische Form

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Control
Human tooth sections

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable