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MAB5596

Sigma-Aldrich

Anti-HCN2 Antibody

culture supernatant, Chemicon®

Synonym(e):

Hyperpolarization-activated and cyclic nucleotide-gated channel 2

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rat

Qualitätsniveau

Antikörperform

culture supernatant

Antikörper-Produkttyp

primary antibodies

Klon

monoclonal

Speziesreaktivität

mouse, rat

Hersteller/Markenname

Chemicon®

Methode(n)

immunohistochemistry: suitable
western blot: suitable

Isotyp

IgG1

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

mouse ... Hcn2(15166)
rat ... Hcn2(114244)

Spezifität

HCN2 (Hyperpolarization-activated and cyclic nucleotide-gated channel 2). The antibody recognizes both the glycosyated and deglycosylated form of HCN2. The antibody recognizes a weak band at ~98 kDa and a stronger band at ~108 kDa in glycosylated protein from a retinal membrane preparation.

Immunogen

Synthetic peptide from rat HCN2.

Anwendung

Research Category
Neurowissenschaft
Research Sub Category
Ionenkanäle & -transporter
Anti-HCN2 Antibody is an antibody against HCN2 for use in IH & WB.
Western blot on rat and mouse retina. The antibody recognizes a weak band at ~98 kDa and a stronger band at ~108 kDa in glycosylated protein from a retinal membrane preparation.

Immunohistochemistry on rat and mouse retina.

Optimal working dilutions must be determined by end user.

Physikalische Form

Cultured supernatant containing 0.05% sodium azide.

Lagerung und Haltbarkeit

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Frank Müller et al.
The European journal of neuroscience, 17(10), 2084-2096 (2003-06-06)
Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels codetermine the integrative behaviour of neurons and shape their response to synaptic stimulation. We used immunohistochemistry and patch-clamp recording to study the composition and distribution of HCN channels in the rat retina. All four
Joon Ha Park et al.
International journal of molecular medicine, 44(5), 1801-1810 (2019-10-02)
Hyperpolarization‑activated cyclic nucleotide‑gated (HCN) channels have been known to participate in the regulation of neuronal excitability, synaptic transmission and long‑term potentiation in the hippocampus. The present study investigated transient ischemia‑induced changes of HCN1 and HCN2 expressions in the Cornu Ammonis
Stuart M Cain et al.
Pflugers Archiv : European journal of physiology, 467(6), 1367-1382 (2014-06-24)
Burst-firing in distinct subsets of thalamic relay (TR) neurons is thought to be a key requirement for the propagation of absence seizures. However, in the well-regarded Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model as yet there has been no

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