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MAB4122

Sigma-Aldrich

Anti-Multi-Drug Resistance Related Protein Antibody, clone MRPm6

culture supernatant, clone MRPm6, Chemicon®

Synonym(e):

MRP

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

300

Antikörperform

culture supernatant

Antikörper-Produkttyp

primary antibodies

Klon

MRPm6, monoclonal

Speziesreaktivität

human

Hersteller/Markenname

Chemicon®

Methode(n)

flow cytometry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

Isotyp

IgG1

NCBI-Hinterlegungsnummer

NM_004996.3
NM_019862.2
NM_019898.2
NM_019899.2
NM_019900.2
NM_019901.1
NM_019902.1

UniProt-Hinterlegungsnummer

P33527

Versandbedingung

wet ice

Angaben zum Gen

human ... ABCC1(4363)

Verwandte Kategorien

Spezifität

MRPm6 reacts with an internal epitope of MRP, a 180-195 kDa transmembrane transporter protein overexpressed in various human non-P-glycoprotein MDR tumor cell lines. MRPm6 was raised against a bacterial fusion protein of MRP, containing a segment of 170 amino acids in the carboxy terminal end and part of the carboxy proximal nucleotide binding domain of the protein. MRPm6 does not cross-react with the human MDR1 and MDR3 gene products (Flens et al., 1994).

Anwendung

Anti-Multi-Drug Resistance Related Protein Antibody, clone MRPm6 is an antibody against Multi-Drug Resistance Related Protein for use in FC, WB, IH(P).
Western blot

Flow Cytometry

Immunohistochemistry on frozen and paraffin embedded tissue

sections: 1:20.

Note: For cellular detection permeabilization is required.

Optimal working dilutions must be determined by end user.

Physikalische Form

Tissue Culture Supernatant. Liquid containing 0.1% sodium azide and 0.7% BSA.

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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M L Den Boer et al.
Leukemia, 11(7), 1078-1085 (1997-07-01)
The clinical relevance of multidrug resistance (MDR)-related proteins in childhood acute lymphoblastic leukemia (ALL) is largely unknown. The diversity of techniques, fixation methods, storage of cells (fresh or cryopreserved) etc, may contribute to discrepancies observed between several studies. We therefore
Tissue distribution of the multidrug resistance protein.
Flens, M J, et al.
The American Journal of Pathology, 148, 1237-1247 (1996)
D Schadendorf et al.
The American journal of pathology, 147(6), 1545-1552 (1995-12-01)
Melanoma cells often display a multidrug-resistant phenotype, but the mechanisms involved are largely unknown. We have studied here the recently identified transport-associated proteins, MRP and LRP, and the well-known drug resistance marker P-glycoprotein using a panel of 16 human melanoma

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