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Key Documents

ABE18-AF488

Sigma-Aldrich

Anti-acetyl Histone H3 (Lys9), Alexa Fluor 488 Conjugate Antibody

from rabbit, ALEXA FLUOR 488

Synonym(e):

Histone H3.1t, H3/t, H3t, H3/g, acetyl Histone H3 (Lys9)

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

Konjugat

ALEXA FLUOR 488

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Speziesreaktivität

human

Speziesreaktivität (Voraussage durch Homologie)

mouse (based on 100% sequence homology), chicken (based on 100% sequence homology)

Methode(n)

immunocytochemistry: suitable

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Posttranslationale Modifikation Target

acetylation (Lys9)

Angaben zum Gen

human ... H3C1(8350)
mouse ... H3C1(360198)

Allgemeine Beschreibung

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. Histone proteins are highly post-translationally modified however Histone H3 is the most extensively modified of the five histones. Histone H3 sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes. Trimethylation of histone H3 on Lys9 (H3K9me3) is one of the most highly studied epigenetic marks. H3K9me3 functions in the repression of euchromatic genes, and in epigenetic control of heterochromatin assembly, most likely by acting as a recognition motif for the binding of chromatin-associated proteins, such as Swi6 or HP1α. The enzymes responsible for H3K9 trimethylation are SUV39H1 and SUV39H2.

Immunogen

Linear peptide corresponding to acetyl Histone H3 (Lys9).

Anwendung

Research Category
Epigenetik & nukleäre Funktionen
Research Sub Category
Nuclear Receptors
This Anti-acetyl Histone H3 (Lys9) is validated for use in Immunocytochemistry for the detection of acetyl Histone H3 (Lys9).

Qualität

Evaluated by Immunocytochemistry in A431 cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected acetyl Histone H3 (Lys9) in A431 cells. ABE18-AF488 is derived from its parent antibody ABE18.
Alexa Fluor is a registered trademark of Life Technologies.

Zielbeschreibung

17 kDa observed. Molecular weight was observed with parent ABE18.

Physikalische Form

Affinity purified
Purified rabbit IgG in PBS containing 15 mg/mL BSA and 0.1% Sodium Azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Sonstige Hinweise

Concentration: Please refer to lot specific datasheet.

Rechtliche Hinweise

ALEXA FLUOR is a trademark of Life Technologies

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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