ABC470

Anti-Kallikrein-5 Antibody/KLK5

from rabbit, purified by affinity chromatography

• Synonym(e): Kallikrein-5, Kallikrein-like protein 2, KLK-L2, Stratum corneum tryptic enzyme, Kallikrein-5/KLK5
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: mouse, human
• Speziesreaktivität (Voraussage durch Homologie): gorilla (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)
• Methode(n): immunohistochemistry: suitable; western blot: suitable
• NCBI-Hinterlegungsnummer: NP_001070959
• UniProt-Hinterlegungsnummer: Q9Y337
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... KLK5(25818)

Beschreibung

Allgemeine Beschreibung

Kallikrein-5/KLK5, or also known as Kallikrein-related peptidase 5, Kallikrein-like protein 2, KLK-L2, and formerly known as Stratum corneum tryptic enzyme (SCTE), is an important enzyme encoded by the gene KLK5/KLK-L2/SCTE. KLK5 is a secreted serine protease enzyme that is expressed in many tissues including the skin, breast and brain. In the skin, Kallikreins-related peptidases (KLKs) are proteases that are important for the desquamation process of the skin (cell shedding). KLK5 is considered as one of the most important KLKs in skin desquamation because KLK5 also regulates the activation of other Kallikreins needed for cell shedding. In disease, KLK5 displays aberrant expression in many cancers. However, expression of KLK5 in some cancer cells appears to suppress tumor growth and activity via reduced RhoA activity and the modulation the mevalonate pathway. This is particularly true in breast cancer and efforts are examining methods to increase KLK5 expression in breast cancer as a form of treatment.

Immunogen

KLH-conjugated linear peptide corresponding to the Peptidase S1 domain of human Kallikrein-5/KLK5.

Anwendung

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Kallikrein-5/KLK5 in human skin cancer sections tissue.

This Anti-Kallikrein-5 Antibody/KLK5 is validated for use in Western Blotting and Immunohistochemistry for the detection of Kallikrein-5/KLK5.

Qualität

Evaluated by Western Blotting in ovcar 3 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Kallikrein-5/KLK5 in 10 µg of ovcar 3 cell lysate.

Zielbeschreibung

~32 kDa observed

Sonstige Hinweise

Concentration: Please refer to lot specific datasheet.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable