ABC138

Anti-DHODH Antibody

from rabbit, purified by affinity chromatography

• Synonym(e): Dihydroorotate dehydrogenase (quinone), mitochondrial, DHOdehase, Dihydroorotate oxidase
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: human
• Methode(n): immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBI-Hinterlegungsnummer: NP_001352
• UniProt-Hinterlegungsnummer: Q02127
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... DHODH(1723)

Beschreibung

Allgemeine Beschreibung

Dihydroorotate oxidase (DHODH) is also called Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase). DHODH is a member the dihydroorotate dehydrogenase (Type 2) family and is involved in pyrimidine biosynthesis. DHODH catalyzes the conversion of dihydroorotate to orotate using quinone as an electron acceptor. DHODH defects can cause postaxial acrofacial dysostosis (POADS).

Spezifität

Other Homologies: Rat (93% sequence homology) and Mouse (86% sequence homology).

This antibody recognizes the Topological Domain (Mitochondrial intermembrane) of DHODH.

Immunogen

Epitope: Topological Domain ( Mitochondrial intermembrane)

KLH-conjugated linear peptide corresponding to the Topological Domain (Mitochondrial intermembrane) of human DHODH.

Anwendung

Research Category
Apoptose & Krebs

Research Sub Category
Apoptose - Weiterführende Produkte

Anti-DHODH Antibody is a rabbit polyclonal antibody, validated for use in western blotting & IHC (Paraffin).

Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected DHODH in human testis and breast carcinoma sections.

Qualität

Evaluated by Western Blotting in T47D cell lysate.

Western Blotting Analysis: 0.25 µg/mL of this antibody detected DHODH in 10 µg of T47D cell lysate.

Zielbeschreibung

~43 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.

Physikalische Form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Control
T47D cell lysate

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable