AB5493
Anti-Sodium Channel Nav1.5 Antibody, pain
Chemicon®, from rabbit
Synonym(e):
SCN5A
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Alle Fotos(1)
About This Item
UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
rabbit
Qualitätsniveau
Antikörperform
affinity purified immunoglobulin
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Aufgereinigt durch
affinity chromatography
Speziesreaktivität
rat
Hersteller/Markenname
Chemicon®
Methode(n)
western blot: suitable
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... SCN5A(6331)
Spezifität
Recognizes Nav1.5 (Scn5a, SKM2). The epitope specific for Nav1.5 is not present in any other known proteins.
SPECIES REACTIVITIES:
The immunogen sequence is identical in mouse and conserved in human (17/19). Reactivity with other species has not yet been tested.
SPECIES REACTIVITIES:
The immunogen sequence is identical in mouse and conserved in human (17/19). Reactivity with other species has not yet been tested.
Immunogen
Highly purified peptide corresponding to residues 493-511 of rat Nav1.5 (Accession P15389).
Anwendung
Research Category
Neurowissenschaft
Neurowissenschaft
Research Sub Category
Ionenkanäle & -transporter
Ionenkanäle & -transporter
Anti-Sodium Channel Nav1.5 Antibody, pain is an antibody against Sodium Channel Nav1.5 for use in WB.
Western blotting: 1:200 using ECL on rat heart membranes. See suggested protocol.
Dilutions should be made using a carrier protein such as BSA (1-3%).
Optimal working dilutions must be determined by the end user.
Dilutions should be made using a carrier protein such as BSA (1-3%).
Optimal working dilutions must be determined by the end user.
Physikalische Form
Affinity purified immunoglobulin. Lyophilized from PBS, pH 7.4, containing 1% BSA, and 0.05% sodium azide. Reconstitute with 50 μL of sterile distilled water. Centrifuge antibody preparation before use (10,000 x g for 5 min).
Lagerung und Haltbarkeit
Maintain lyophilized material at -20°C for up to 6 months from date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Hinweis zur Analyse
Control
Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). For negative control, preincubate 1 μg of purified peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). For negative control, preincubate 1 μg of purified peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
Sonstige Hinweise
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Rechtliche Hinweise
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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H-Sätze
P-Sätze
Gefahreneinstufungen
Aquatic Chronic 3
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Experimental and therapeutic medicine, 13(2), 771-779 (2017-03-30)
The impact of heart failure (HF) on sinoatrial node (SAN) channel regulation and electropharmacological responses has remained elusive. The present study aimed to investigate the effects of HF on the electrical activity of SANs with and without pharmacological interventions. Action
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The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(27), 10101-10114 (2011-07-08)
Many primary vestibular afferents form large cup-shaped postsynaptic terminals (calyces) that envelope the basolateral surfaces of type I hair cells. The calyceal terminals both respond to glutamate released from ribbon synapses in the type I cells and initiate spikes that
NaV1.5 sodium channel window currents contribute to spontaneous firing in olfactory sensory neurons.
Christopher T Frenz et al.
Journal of neurophysiology, 112(5), 1091-1104 (2014-05-30)
Olfactory sensory neurons (OSNs) fire spontaneously as well as in response to odor; both forms of firing are physiologically important. We studied voltage-gated Na(+) channels in OSNs to assess their role in spontaneous activity. Whole cell patch-clamp recordings from OSNs
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