AB5403
Anti-NMDAR2B Antibody, phosphoTyr 1472
Chemicon®, from rabbit
Synonym(e):
Anti-DEE27, Anti-EIEE27, Anti-GluN2B, Anti-MRD6, Anti-NMDAR2B, Anti-NR2B, Anti-NR3, Anti-hNR3
Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)
About This Item
UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
rabbit
Qualitätsniveau
Antikörperform
affinity purified immunoglobulin
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Aufgereinigt durch
affinity chromatography
Speziesreaktivität
rat
Hersteller/Markenname
Chemicon®
Methode(n)
western blot: suitable
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
rat ... Grin2B(24410)
Spezifität
NMDAR2B, phosphoTyr1472. The antibody recognizes a protein of ~180 kDa in Western blot. The labeling of the NMDAR2B protein in Western blots of rat brain is blocked by the phosphopeptide but not by the dephosphopeptide. Two additional lower molecular weight bands are present in Western blots of rat brain.
Immunogen
Epitope: phosphoTyr 1472
Synthetic peptide corresponding to amino acids surrounding the phosphoTyr1472 of rat NMDAR2B.
Anwendung
Research Category
Neurowissenschaft
Neurowissenschaft
Research Sub Category
Neurotransmitter & Rezeptoren
Neurotransmitter & Rezeptoren
Anti-NMDAR2B Antibody, phosphoTyr 1472 is an antibody against NMDAR2B for use in WB.
Western blot: 1:1,000
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Physikalische Form
Affinity purified immunoglobulin. Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl with 100 μg/mL BSA, 50% glycerol and 0.09% sodium azide.
Lagerung und Haltbarkeit
Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.
Rechtliche Hinweise
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 2
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Sofia Lopes et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(26), E3755-E3763 (2016-06-09)
Exposure to chronic stress is frequently accompanied by cognitive and affective disorders in association with neurostructural adaptations. Chronic stress was previously shown to trigger Alzheimer's-like neuropathology, which is characterized by Tau hyperphosphorylation and missorting into dendritic spines followed by memory
Hong-Bin Yang et al.
Journal of neurochemistry, 116(1), 93-104 (2010-11-09)
Selective inhibition of GluN2B-containing NMDA receptor (GluN2BR) in spinal dorsal horn effectively alleviates inflammatory pain, suggesting the up-regulation of GluN2BR function involved in central sensitization. Previous studies have demonstrated that the increase in GluN2BR synaptic expression serves as a key
Sehoon Won et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(32), E4736-E4744 (2016-07-28)
Phosphorylation regulates surface and synaptic expression of NMDA receptors (NMDARs). Both the tyrosine kinase Fyn and the tyrosine phosphatase striatal-enriched protein tyrosine phosphatase (STEP) are known to target the NMDA receptor subunit GluN2B on tyrosine 1472, which is a critical
Jérémy Ferrier et al.
PloS one, 8(10), e77828-e77828 (2013-11-10)
Oxaliplatin is an anticancer drug used for the treatment of advanced colorectal cancer, but it can also cause painful peripheral neuropathies. The pathophysiology of these neuropathies has not been yet fully elucidated, but may involve spinal N-methyl-D-aspartate (NMDA) receptors, particularly
Anterior Cingulate Cortex Mediates Hyperalgesia and Anxiety Induced by Chronic Pancreatitis in Rats.
Dan Ren et al.
Neuroscience bulletin, 38(4), 342-358 (2021-12-16)
Central sensitization is essential in maintaining chronic pain induced by chronic pancreatitis (CP), but cortical modulation of painful CP remains elusive. Here, we examined the role of the anterior cingulate cortex (ACC) in the pathogenesis of abdominal hyperalgesia in a
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