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AB2989

Sigma-Aldrich

Anti-Metadherin Antibody

from rabbit, purified by affinity chromatography

Synonym(e):

Astrocyte elevated gene-1 protein, Lysine-rich CEACAM1 co-isolated protein, Metastasis adhesion protein, astrocyte elevated gene-1

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Aufgereinigt durch

affinity chromatography

Speziesreaktivität

human, mouse

Methode(n)

immunocytochemistry: suitable
western blot: suitable

Isotyp

IgG

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... MTDH(92140)

Allgemeine Beschreibung

Metadherin is a type 2 transmembrane protein who′s overexpression was first described in breast cancers. It plays an important role in the metastasis of breast cancers into the lungs as a secondary site of development. Antibodies reactive to the lung-homing domain of metadherin and siRNA-mediated knockdown of metadherin expression in breast cancer cells inhibited experimental lung metastasis, indicating that tumor cell metadherin mediates localization at the metastatic site (Brown, 2009).

Spezifität

The antibody recognizes Metadherin at and around the homing domain.

Immunogen

Epitope: Homing domain
Recombinant GST-tagged proteins corresponding at or around the lung homing domain of mouse Metadherin.

Anwendung

Research Category
Zellstruktur
Research Sub Category
Adhäsions-Proteine (CAMs – Zelladhäsionsmoleküle)
Anti-Metadherin Antibody is an antibody against Metadherin for use in WB & IC.
Western blot Analysis: 0.25 µg/ml of this antibody detected Metadherin in 10 µg of HEK293, HepG2, and Jurkat cell lysates.

Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected Metadherin in NIH/3T3 and HeLa cells.

Qualität

Evaluated by Western blot in HeLa cell lysate.

Western blot Analysis: 0.25 µg/ml of this antibody detected Metadherin in 10 µg of HeLa cell lysate.

Zielbeschreibung

~ 75 kDa

Physikalische Form

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Control
HeLa cell lysate

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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Jodi E Eipper-Mains et al.
RNA (New York, N.Y.), 17(8), 1529-1543 (2011-06-29)
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Sung-Suk Suh et al.
PLoS genetics, 10(10), e1004652-e1004652 (2014-10-24)
Metastasis is the principal cause of cancer death and occurs through multiple, complex processes that involve the concerted action of many genes. A number of studies have indicated that the Fragile Histidine Triad (FHIT) gene product, FHIT, functions as a

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