8.55008

Sieber Amide resin

Novabiochem^®

• Synonym(e): 9-Fmoc-amino-xanthen-3-yloxy-Merrifield resin
• CAS-Nummer: 915706-90-0
• UNSPSC-Code: 12352111
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 400
• Produktlinie: Novabiochem^®
• Form: beads
• Eignung der Reaktion: reaction type: Fmoc solid-phase peptide synthesis
• Hersteller/Markenname: Novabiochem^®
• Anwendung(en): peptide synthesis
• Funktionelle Gruppe: amine
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

A hyper acid-labile resin for the Fmoc SPPS of protected peptide amides via mild 1% TFA cleavage ^[1,2]. The resin can be readily reductively alkylated to provide a support suited to the synthesis of secondary carboxamides ^[3].This resin has also been employed to produce protected peptide fragments in which the C-terminal carboxylic acid group is blocked as a hydroxymethylphenoxy-β-alaninamide ester ^[4] .

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Anwendung

• Determining the Hydrophobicity Index of Protected Amino Acids and Common Protecting Groups: Discusses the synthesis of peptide sequences using Sieber Amide resin for its acid-labile properties. (Gavva et al., 2023).
• Smart biomaterials: Surfaces functionalized with proteolytically stable osteoblast-adhesive peptides: Utilizes Sieber Amide resin for surface functionalization techniques in biomaterials. (Zamuner et al., 2017).
• A 99mTc-tricine-HYNIC-labeled peptide targeting the melanocortin-1 receptor for melanoma imaging: Describes the use of Sieber Amide resin in the synthesis of radiolabeled peptides for diagnostic imaging. (Shamshirian et al., 2016).

Verlinkung

Replaces: 01-64-0059

Hinweis zur Analyse

Farbe (visuell): weiß bis hellgelb bis beige
Aussehen der Substanz (visuell): Kügelchen
Beladung (Photometrische Bestimmung des Fmoc-Chromophors nach Abspaltung mit DBU/DMF): 0.40 - 0.80 mmol/g
Aufquellvolumen (in DMF): chargen- spezifischer Wert
Aufquellvolumen (in CH₂Cl₂): chargen- spezifischer Wert
Gesamtes Aufquellvolumen nach Houben Weyl (in CH₂Cl₂): ≥ 5.2 ml/g
Gesamtes Aufquellvolumen nach Houben Weyl (in DMF): ≥ 5.2 ml/g
Die Polymermatrix ist Copoly (Styrol - 1% DVB), 100-200 mesh

Rechtliche Hinweise

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable