567310-M

SKF-96365, Hydrochloride

Inhibits receptor-mediated Ca²⁺ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca²⁺ release.

• Synonym(e): SKF-96365, Hydrochloride, 1-[β-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole, HCl
• Empirische Formel (Hill-System): C₂₂H₂₆N₂O₃ · xHCl
• CAS-Nummer: 130495-35-1
• Molekulargewicht: 366.45 (free base basis)
• MDL-Nummer: MFCD00236407
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (TLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze
• Farbe: white
• Löslichkeit: water: 2 mg/mL
• Lagertemp.: 10-30°C
• InChI: 1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H
• InChIKey: FWLPKVQUECFKSW-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Inhibits receptor-mediated Ca²⁺ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca²⁺ release. Also inhibits voltage-gated Ca²⁺ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.

Inhibits receptor-mediated Ca²⁺ entry in stimulated platelets (IC₅₀ = 8-12 µM in intact platelets), neutrophils, and endothelial cells (IC₅₀ = 30 µM for human endothelial cells) at concentrations that do not affect internal Ca²⁺ release. Also inhibits voltage-gated Ca²⁺ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.

Biochem./physiol. Wirkung

Primary Target
Inhibits receptor-mediated Ca2+ entry

Warnhinweis

Toxicity: Irritant (B)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Sonstige Hinweise

Leung, Y.-M., et al. 1996. Biochem. Pharmacol.51, 605.
Schwartz, G., et al. 1994. Cell Calcium15, 45.
Cabello, O.A. and Schilling, W.P. 1993. Biochem. J. 295, 357.
Graier, W.F., et al. 1992. Biochem. Biophys. Res. Commun. 186, 1539.
Blayney, L.M., et al. 1991. Biochem. J. 273, 803.
Fasolato, C., et al. 1990. J. Biol. Chem. 265, 20351.
Merritt, J.E., et al. 1990. Biochem. J.271, 515.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable