5.05875

(+)-Bicuculline

• Synonym(e): (+)-Bicuculline, GABA _A Receptor Antagonist, Bicuculline
• Empirische Formel (Hill-System): C₂₀H₁₇NO₆
• CAS-Nummer: 485-49-4
• Molekulargewicht: 367.35
• MDL-Nummer: MFCD00005006
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥99% (HPLC)
• Qualitätsniveau: 100
• Form: solid
• Wirksamkeit: 740 nM IC₅₀
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: pale yellow
• Löslichkeit: DMSO: soluble
• Lagertemp.: −20°C
• InChI: 1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
• InChIKey: IYGYMKDQCDOMRE-ZWKOTPCHSA-N

Beschreibung

Allgemeine Beschreibung

A potent allosteric antagonist of vertebrate GABA_A receptors. Blocks GABA_A-induced chloride currents in cultured neurons (IC₅₀ = 740 nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions.

Warnhinweis

Toxicity: Toxic (F)

Sonstige Hinweise

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Ueno, S., et al. 1997. J. Neurosci.17, 625.
Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89.
Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol.230, 187.
Robert K.A., et al. 1993. Cardiovasc. Pharmacol.21, 156.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS06,GHS09
• Signalwort: Danger
• H-Sätze: H300 + H310 + H330 - H400
• P-Sätze: P260 - P262 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Gefahreneinstufungen: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1
• Lagerklassenschlüssel: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable