5.04844

7-Chlorokynurenic Acid Sodium Salt

• Synonym(e): 7-Chlorokynurenic Acid Sodium Salt, 7-Chloro-4-hydroxyquinoline-2-carbo-xylic acid sodium salt
• Empirische Formel (Hill-System): C₁₀H₅ClNNaO₃
• CAS-Nummer: 1263094-00-3
• Molekulargewicht: 245.59
• UNSPSC-Code: 12352106
• NACRES: NA.77

Eigenschaften

• Assay: ≥99% (HPLC)
• Qualitätsniveau: 100
• Form: solid
• Wirksamkeit: 0.56 μM IC₅₀
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: white
• Löslichkeit: water: 100 mM
• Lagertemp.: 2-8°C
• InChI: 1S/C10H6ClNO3.Na/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13;/h1-4H,(H,12,13)(H,14,15);/q;+1/p-1
• InChIKey: IFZYIORLNGNLEI-UHFFFAOYSA-M

Beschreibung

Allgemeine Beschreibung

A very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (IC₅₀ = 0.56 µM). Also a potent inhibitor of glutamate transporter. Often used in studies of neuroprotection and schizophrenia.

Biochem./physiol. Wirkung

Primary Target
NMDA receptors

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Kemp, J., et al. 1988. Proc. Natl. Acad. Sci. U.S.A.85, 6550.
Kretschmer, D., et al. 1995. Eur. J. Pharmacol.280, 37.
Bartlett, D., et al. 1999. Neuropharmacol.37, 839.
Moroni, F., et al. 1991. Eur. J. Pharmacol.199, 32.
Stone, W., et al. 2012. FEBS J.279, 1386.
Vécsei, L., et al. 2012. Nat. Rev. Drug Disc.12, 64.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable