5.00554

MHY1485

≥97% (HPLC), solid, mTOR activator, Calbiochem^®

• Synonym(e): mTOR Activator, MHY1485, 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine, Autophagy Inhibitor III
• Empirische Formel (Hill-System): C₁₇H₂₁N₇O₄
• CAS-Nummer: 326914-06-1
• Molekulargewicht: 387.39
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 2026662
• NACRES: NA.77

Eigenschaften

• product name: mTOR Activator, MHY1485,
• Assay: ≥97% (HPLC)
• Qualitätsniveau: 100
• Form: solid
• Wirksamkeit: ~2 μM IC₅₀
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: pale yellow
• Löslichkeit: DMSO: 12.5 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC(=NN3)C4=CC=CC=C4O

Beschreibung

Allgemeine Beschreibung

MHY1485, a small-molecule activator of the mammalian target of rapamycin (mTOR), exerts an inhibitory effect on the autophagic process by preventing the fusion between autophagosomes and lysosomes, resulting in the accumulation of LC3II protein and the enlargement of autophagosomes. It can also protect osteoblasts from dexamethasone-induced damage by inhibiting the mitochondrial death pathway provoked by dexamethasone.

Anwendung

mTOR Activator, MHY1485 has been used to activate the mammalian target of rapamycin (mTOR) pathway in mice with Parkinson disease (PD) to reverse the effects of tumor necrosis factor α–induced protein 3 (TNFAIP3) on the mitigation of injury in mice and in SK-N-SH cells induced with 1-Methyl-4-phenylpyridinium (MPP+).

Biochem./physiol. Wirkung

Cell permeable: yes

Reversible: yes

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Choi, Y. J., et al. 2012. PLoS. One.7, e43418.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable