420210

Jervine

A cell-permeable steroidal alkaloid similar to cyclopamine that displays teratogenic effects and induces cyclopia by blocking Sonic Hedgehog signaling.

• Synonym(e): Jervine, (3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one, 11-Ketocyclopamine, Shh Signaling Antagonist III
• Empirische Formel (Hill-System): C₂₇H₃₉NO₃
• CAS-Nummer: 469-59-0
• Molekulargewicht: 425.60
• MDL-Nummer: MFCD01684066
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze
• Farbe: off-white
• Löslichkeit: ethanol: 10 mg/mL; DMSO: 5 mg/mL
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• InChI: 1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3
• InChIKey: CLEXYFLHGFJONT-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable steroidal alkaloid similar to cyclopamine (Cat. No. 239803) that displays teratogenic effects and induces cyclopia by blocking shh (Sonic Hedgehog) signaling (IC₅₀ = ~ 500-700 nM in s12 cells). Tomatidine (Cat. No. 614350) serves as a suitable negative control.

A cell-permeable steroidal alkaloid similar to cyclopamine (Cat. No. 239803) that displays teratogenic effects and induces cyclopia by blocking shh (Sonic Hedgehog) signaling (IC₅₀ ~500-700 nM in s12 cells). Tomatidine (Cat. No. 614350) serves as a suitable negative control.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
Induces cyclopia by blocking shh (Sonic Hedgehog) signaling

Product does not compete with ATP.

Reversible: no

Target IC₅₀: ~ 500-700 nM blocking shh (Sonic Hedgehog) signaling in s12 cells

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Toxic (F)

Angaben zur Herstellung

Slight warming may be required to achieve complete solubilization in ethanol.

Rekonstituierung

Following reconstitution in fresh DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Williams, J.A., et al. 2003. Proc. Natl. Acad. Sci. USA100, 4616.
Cooper, M. K., et al. 2003. Nat. Genet.33, 508.
Mistretta, C.M., 2003. Dev. Biol.254, 1.
ten Berge, D., et al. 2001. Development128, 2929.
Cooper, M.K., et al. 1998. Science280, 1603.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H301,H360D
• P-Sätze: P201 - P202 - P264 - P270 - P280 - P301 + P310
• Gefahreneinstufungen: Acute Tox. 3 Oral - Repr. 1B
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable