382149

Histone Deacetylase Inhibitor III

The Histone Deacetylase Inhibitor III, also referenced under CAS 251456-60-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Synonym(e): Histone Deacetylase Inhibitor III, M344, 4-Dimethylamino- N-(6-hydroxycarbamoylhexyl)benzamide, N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide, M344, 4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)benzamide, N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide
• Empirische Formel (Hill-System): C₁₆H₂₅N₃O₃
• CAS-Nummer: 251456-60-7
• Molekulargewicht: 307.39
• MDL-Nummer: MFCD03453554
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: white
• Löslichkeit: DMSO: 1 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C
• InChI: 1S/C16H25N3O3/c1-19(2)14-10-8-13(9-11-14)16(21)17-12-6-4-3-5-7-15(20)18-22/h8-11,22H,3-7,12H2,1-2H3,(H,17,21)(H,18,20)
• InChIKey: MXWDSZWTBOCWBK-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylases (IC₅₀ = 40 nM for rat liver HDAC and IC₅₀ = 100 nM for maize HD). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells.

A cell-permeable, amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylase (IC₅₀ = 40 nM for rat liver HDAC and IC₅₀ = 100 nM for maize HDAC). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
Rat liver HDAC

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 40 nM for rat liver HDAC

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Sonstige Hinweise

Ramiszewski, S.W., et al. 2002. J. Med. Chem.45, 753.
Jung, M., et al. 1999. J. Med. Chem.42, 4669.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable