233552-M

Cobra Venom Factor, Naja naja kaouthia

Cobra Venom Factor, Naja naja kaouthia, is a native cobra venom factor. Glycoprotein composed of three non-identical disulfide-bonded subunits of 68, 48, and 30 kDa.

• Synonym(e): Cobra Venom Anticomplementary Protein
• UNSPSC-Code: 12352202

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (SDS-PAGE)
• Form: liquid
• Spezifische Aktivität: ≥250 units/mL
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; avoid repeated freeze/thaw cycles
• Fremdaktivität: Phospholipase, none detected
• Lagertemp.: −70°C

Beschreibung

Allgemeine Beschreibung

Native cobra venom factor from Naja naja kaouthia. Glycoprotein composed of three non-identical disulfide-bonded subunits with M.W. of 68 kDa (α), 48 kDa (β), and 30 kDa (γ). Cobra venom factor (CVF) is a structural and functional analog of cobra, as well as mammalian C3. Thus, in the presence of Factor B, Factor D, and Mg²⁺, CVF can form a stable CVF,Bb complex that is a C3/C5 convertase enzyme; however, the CVF,Bb complex is not susceptible to regulation by Factors H and I. Four to six µg of purified CVF are equal to 1.0 unit of functional activity as measured by the method of Cochrane, et al.

Native cobra venom factor from Naja naja kaouthia. Glycoprotein composed of three nonidentical disulfide-bound subunits with M.W. of 68,000 (α), 48,000 (β), and 30,000 (γ). Cobra Venom Factor (CVF) is a structural and functional analog of cobra, as well as mammalian C3. In the presence of Factor B, Factor D, and Mg²⁺, CVF can form a stable CVF, Bb complex which is a C3/C5 convertase enzyme; however, the CVF,Bb complex is not susceptible to regulation by Factors H and I. Four to six µg of purified CVF is equal to 1.0 unit of functional activity as measured by the method of Cochrane, et al.

Warnhinweis

Toxicity: Harmful (C)

Sonstige Hinweise

Bogers, W.M., et al. 1993. Eur. J. Immunol.23, 433.
Fritzinger, D.C., et al. 1992. J. Immunol. 149, 3554.
Muller, B. and Muller-Ruchholtz, W. 1987. Leuk. Res.11, 461.
Vogel, C.W. and Muller-Eberhard, H.J. 1984. J. Immunol. Methods73, 203.
Cochrane, C.G., et al. 1970. J. Immunol. 105, 55.
Ballows, M. and Cochrane, C.G. 1969. J. Immunol.103, 944.

Rechtliche Hinweise

Not available for sale outside the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable