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Merck

1.50656

Supelco

SeQuant ZIC®-cHILIC 100Å (3 µm) HPLC Columns

L x I.D. 100 mm x 2.1 mm HPLC Column, PEEK-lined stainless steel

Synonym(e):

Zwitterionic Hydrophilic Interaction Liquid Chromatography HPLC Column

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

UNSPSC-Code:
41115709
NACRES:
SB.52

product name

SeQuant ZIC-cHILIC 3µm,100Å 50 x 2.1 mm, PEEK-lined stainless steel column, suitable for HPLC

Materialien

PEEK-lined stainless steel column

Qualitätsniveau

Agentur

suitable for USP L114

Produktlinie

SeQuant

Leistungsmerkmale

endcapped: no

Parameter

550 bar pressure
70 °C max. temp.

Methode(n)

HPLC: suitable
LC/MS: suitable
UHPLC-MS: suitable
UHPLC: suitable
mass spectrometry (MS): suitable (High)

Säule L × ID

5 cm × 2.1 mm

Matrix

fully porous particle

Aktive Matrixgruppe

ZIC-HILIC bonding phase

Partikelgröße

3 μm

Porengröße

100 Å pore size

Betriebs-pH-Wert

2-7.5

Trenntechnik

hydrophilic interaction (HILIC)

Lagertemp.

no temp limit

Allgemeine Beschreibung

SeQuant ZIC®-HILIC Columns are designed to retain and separate all types of polar and hydrophilic compounds and for robust chromatography with high selectivity and reproducibility. The silica-based ZIC®-HILIC sorbent has a bonded stationary phase consisting of a highly polar, permanent zwitterion. Separation selectivity is favored by the 1:1 zwitterion charge balance, which makes the ZIC®-HILIC Column overall neutral, with weak, but important, ionic interactions. Tuning of the selectivity on the ZIC®-HILIC Column during method development is facilitated by the pH-inpendent permanent zwitterion, ensuring that only the analytes (and not the column) are affected during eluent optimization.The Pore size of 100 Å makes this column perfectly suitable for the separation of small polar molecules under HILIC conditions.The column dimension of 50 mm length x 2.1 mm ID is the optimal choice for the fast separation of polar compounds using a UHPLC or optimized HPLC Instrument providing low dwell volumes.Thanks to their favorable retention and robust performance, SeQuant HILIC columns have become extremely popular in numerous laboratories around the world. For example, US FDA (United States Food and Drug Administration) has recommended SeQuant ZIC®-HILIC for analysis of melamine and related substances. SeQuant HILIC columns excel in stability and low bleed. These features make them particularly suitable for LC-MS applications where high background can lead to signal suppression and interference with quantitative measurements while also increasing instrument wear. Their high stability makes these high-performance HILIC columns also attractive for traditional HPLC applications.Learn more about the Supelco HPLC Column portfolio and Method development:Brochure: HPLC and UHPLC Column Selection Guide Brochure: A Practical Guide to HPLC - Method Development Guide

Anwendung




  • Evaluation of hydrophilic interaction chromatography versus reversed-phase chromatography for fast aqueous species distribution analysis of Nickel(II)-Histidine complex species.: This research compares ZIC-cHILIC with reversed-phase chromatography for analyzing nickel-histidine complexes, emphasizing ZIC-cHILIC′s efficiency in fast aqueous species distribution (Alsaeedi et al., 2023).


  • Hydrophilic interaction liquid chromatography-electrospray ionization mass spectrometry combined with fabric phase sorptive extraction for therapeutic drug monitoring of pioglitazone, repaglinide, and nateglinide in human plasma.: The study utilizes ZIC-cHILIC in conjunction with mass spectrometry for effective therapeutic drug monitoring in plasma, demonstrating its application in clinical pharmacokinetics (Stamou et al., 2023).


  • Comprehensive evaluation of zwitterionic hydrophilic liquid chromatography stationary phases for oligonucleotide characterization.: This article provides a comprehensive assessment of ZIC-cHILIC for oligonucleotide analysis, showcasing its strengths in nucleotide separation and characterization (Lardeux et al., 2023).


  • HILIC-MS for Untargeted Profiling of the Free Glycation Product Diversity.: The research highlights the use of ZIC-cHILIC in untargeted metabolomics, specifically in profiling glycation products, demonstrating its versatility in metabolite analysis (Yan et al., 2022).




Rechtliche Hinweise

SeQuant is a trademark of Merck KGaA, Darmstadt, Germany
ZIC is a registered trademark of Merck KGaA, Darmstadt, Germany
ZIC-HILIC is a trademark of Merck KGaA, Darmstadt, Germany

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