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Merck
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14-439-M

Sigma-Aldrich

MAP Kinase 1/Erk1 Protein, active, 10 µg

Active, recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag, for use in Kinase Assays.

Synonym(e):

ERT1, Extracellular signal-regulated kinase 2 (ERK-2), MAPK 1, Mitogen-activated protein kinase 1, p44 MAPK

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About This Item

UNSPSC-Code:
12352202
eCl@ss:
32160405
NACRES:
NA.32

Biologische Quelle

human

Qualitätsniveau

100

Rekombinant

expressed in E. coli

Form

liquid

Mol-Gew.

Mw 69.9 kDa

Hersteller/Markenname

Upstate®

Methode(n)

activity assay: suitable (kinase)

Farbe

colorless

Löslichkeit

water: soluble

NCBI-Hinterlegungsnummer

NM_002745.4
NM_138957.3

UniProt-Hinterlegungsnummer

P28482

Angaben zum Gen

human ... MAPK3(5595)

Allgemeine Beschreibung

Research area: Cell Signaling

Recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag

Biochem./physiol. Wirkung

Extracellular-signal-regulated kinase 1 (ERK1)/ Extracellular-signal-regulated kinase 2 (ERK2), as part of the Ras-Raf-MEK-ERK signal transduction cascade, are involved in regulating a wide range of cellular processes, including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcriptional control. Additionally, ERK1 signaling contributes to the regulation of cyclin D1 expression during the cell cycle. MAP kinases play a crucial role in inflammation and immune responses by regulating the production of pro- and anti-inflammatory cytokines, as well as prostaglandins, in response to lipopolysaccharide (LPS) stimulation.

Verpackung

Also available in 250μg size as catalog # 14-439M - Call for pricing and availability.

Qualität

routinely evaluated by phosphorylation of MBP

Physikalische Form

Purified by glutathione-agarose. Activated with MEK1 and repurified on Ni2+/NTA agarose

Sonstige Hinweise

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Y Zhang et al.
The Journal of biological chemistry, 276(24), 20913-20923 (2001-03-30)
Ultraviolet light A (UVA) plays an important role in the etiology of human skin cancer, and UVA-induced signal transduction has a critical role in UVA-induced skin carcinogenesis. The upstream signaling pathways leading to p70(S6K) phosphorylation and activation are not well
Lucinda F Reynolds et al.
The Journal of biological chemistry, 279(18), 18239-18246 (2004-02-07)
Vav1 is a signaling protein required for both positive and negative selection of CD4(+)CD8(+) double positive thymocytes. Activation of the ERK MAPK pathway is also required for positive selection. Previous work has shown that Vav1 transduces T cell receptor (TCR)

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