1.37165

Spermidin

EMPROVE^® EXPERT

• Synonym(e): 1,8-Diamino-4-azaoctan, N-(3-Aminopropyl)-1,4-diaminobutan
• Lineare Formel: NH₂(CH₂)₃NH(CH₂)₄NH₂
• CAS-Nummer: 124-20-9
• Molekulargewicht: 145.25
• Beilstein: 1698591
• MDL-Nummer: MFCD00008229
• UNSPSC-Code: 12352103
• EG-Index-Nummer: 204-689-0

Eigenschaften

• Biologische Quelle: synthetic
• Qualitätsniveau: 500
• Qualität: GMO free; GMP
• Beschreibung: Aflatoxin-free; Melamin-free; DNase-free; RNase-free
• Produktlinie: EMPROVE^® EXPERT
• Verunreinigungen: low in endotoxins
• Brechungsindex: n20/D 1.479 (lit.)
• Partikelgröße: (liquid or solidified mass)
• Dichte: 0.925 g/mL at 25 °C (lit.)
• Anwendung(en): pharma/biopharma processes; pharmaceutical
• Lagertemp.: 15-25°C
• SMILES String: NCCCCNCCCN
• InChI: 1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
• InChIKey: ATHGHQPFGPMSJY-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Finding the right critical raw material that matches your quality expectation can be challenging. Especially if you are advancing through clinical phases, changing regulatory requirements can raise several questions.

As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Anwendung

Spermidine has several applications that are going beyond its chemical behavior as a base. The amino groups can interact with the phosphate groups of DNA and RNA and stabilize them. In addition, spermidine has a positive impact on transcription by RNA polymerases and can be found in several buffers. Within RNA bioprocessing, spermidine can be used for purification to bind and precipitate DNA. It may also be considered as adjuvant for mRNA vaccines.

The EMPROVE^® Expert quality grade provided with this product is tested for microbial and endotoxin levels and is RNase and DNase free. Stability studies according to ICH Q7 are running and stability conclusions will be available via EMPROVE^® Suite.

Biochem./physiol. Wirkung

Hemmt die neuronale Stickoxidsynthase (nNOS). Bindet und fällt DNA aus; kann zur Aufreinigung von DNA-Bindungsproteinen verwendet werden. Stimuliert die T₄-Polynukleotidkinaseaktivität.

Vorsicht

Für eine sterile Lösung soll die Lösung steril-filtriert und nicht autoklaviert werden. Spermidin deaminiert mit der Zeit; Lösungen tiefgekühlt lagern. Regelmässig frische Lösungen zubereiten.

Rechtliche Hinweise

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS05
• Signalwort: Danger
• H-Sätze: H314
• P-Sätze: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Gefahreneinstufungen: Eye Dam. 1 - Skin Corr. 1B
• Lagerklassenschlüssel: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): 233.6 °F - closed cup
• Flammpunkt (°C): 112 °C - closed cup