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Merck
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Key Documents

07-453

Sigma-Aldrich

Anti-B-Raf Antibody

Upstate®, from rabbit

Synonym(e):

Anti-B-RAF1, Anti-B-raf, Anti-BRAF-1, Anti-BRAF1, Anti-NS7, Anti-RAFB1

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Speziesreaktivität

human, rat, mouse

Hersteller/Markenname

Upstate®

Methode(n)

immunoprecipitation (IP): suitable
western blot: suitable

Isotyp

IgG

NCBI-Hinterlegungsnummer

NM_004333

UniProt-Hinterlegungsnummer

P15056

Versandbedingung

dry ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... BRAF(673)
mouse ... Braf(109880)
rat ... Rasd1(64455)

Spezifität

full length recombinant BRaf (plus 6His tag) and B-Raf splice variants in cell lysates

Immunogen

synthetic peptide corresponding to amino acids 754-765 of human B-Raf

Anwendung

Research Category
Zelluläre Signaltransduktion
Research Sub Category
MAP-Kinasen
This Anti-B-Raf Antibody is validated for use in IP, WB for the detection of B-Raf. This B-Raf antibody has been tested in Human, Mouse, and Rat.

Qualität

routinely evaluated by immunoblot in RIPA lysates from PC12 cells and the full length purified B-Raf, active enzyme

Zielbeschreibung

94kDa

Verlinkung

Replaces: 04-328

Physikalische Form

Protein A chromatography
0.1M Tris-glycine, pH 7.4, 0.15M NaCl,0.05% sodium azide before the addition of glycerol to 30%
Format: Purified

Lagerung und Haltbarkeit

2 years at -20°C

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Gang Ren et al.
International journal of cell biology, 2012, 913242-913242 (2012-05-23)
Recent high-throughput-sequencing of the cancer genome has identified oncogenic mutations in BRaf genetic locus as one of the critical events in melanomagenesis. In normal cells, the activity of BRaf is tightly regulated. Gain-of-function mutations like those identified in melanoma frequently
Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.
Karbowniczek, M; Cash, T; Cheung, M; Robertson, GP; Astrinidis, A; Henske, EP
The Journal of Biological Chemistry null
Sandeep S Joshi et al.
PloS one, 13(2), e0191264-e0191264 (2018-02-27)
Heat shock protein 90 (HSP90) is a molecular chaperone which stabilizes client proteins with important roles in tumor growth. 17-allylamino-17-demethoxygeldanamycin (17-AAG), an inhibitor of HSP90 ATPase activity, occupies the ATP binding site of HSP90 causing a conformational change which destabilizes
Lack of association between BRAF V600E mutation and mitogen-activated protein kinase activation in papillary thyroid carcinoma.
Hui Zuo,Yasushi Nakamura,Hironao Yasuoka,Ping Zhang,Misa Nakamura,Ichiro Mori et al.
Pathology International null
Anne K Voss et al.
The EMBO journal, 25(15), 3652-3663 (2006-07-22)
The mechanisms regulating the size of the cerebral cortex are poorly understood. Here, we demonstrate that the Rap1 guanine nucleotide exchange factor, C3G (Grf2, Rapgef1), controls the size of the cerebral precursor population. Mice lacking C3G show overproliferation of the
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