06-1079

Anti-Interleukin 23 alpha (IL-23A) Antibody

from rabbit, purified by affinity chromatography

• Synonym(e): IL-23 subunit alpha, Interleukin-23 subunit p19, JKA3 induced upon T-cell activation, interleukin 23 p19 subunit, interleukin 23, alpha subunit p19
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: mouse, human
• Speziesreaktivität (Voraussage durch Homologie): rhesus monkey (based on 100% sequence homology)
• Methode(n): flow cytometry: suitable; western blot: suitable
• NCBI-Hinterlegungsnummer: NP_057668
• UniProt-Hinterlegungsnummer: Q9NPF7
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... IL23A(51561)

Beschreibung

Allgemeine Beschreibung

Interleukin-23 subunit alpha (IL-23A or IL-23, p19 subunit) is a subunit of heterodimeric cytokine IL-23, which also contains the p40 subunit of interleukin 12 (IL-12B). The receptor of IL-23 is formed by the beta 1 subunit of IL-12 (IL-12RB1) and an IL-23 specific subunit, IL-23R. IL-23 activates the transcription activator STAT4, and stimulates the production of interferon-gamma. IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration. Recently, IL-23 has been implicated in the development of cancerous tumors. In conjunction with IL-6 and TGF-β1, IL-23 stimulates naive CD4+ T cells to differentiate into a novel subset of cells called Th17 cells, which are distinct from the classical Th1 and Th2 cells. Th17 cells produce IL-17, a proinflammatory cytokine that enhances T cell priming and stimulates the production of proinflammatory molecules such as IL-1, IL-6, TNF-alpha, NOS-2, and chemokines resulting in inflammation.

Spezifität

Antibody recognizes the mature chain of IL-23 subunit alpha.

Immunogen

Epitope: Mature chain of IL-23, subunit alpha.

KLH-conjugated linear peptide corresponding to the mature chain of human IL-23 subunit alpha.

Anwendung

Detect Interleukin 23 alpha (IL-23A) using this Anti-Interleukin 23 alpha (IL-23A) Antibody validated for use in WB, FC.

Flow Cytometry Analysis: 1 µg from a previous lot detected IL-23 alpha in human PBMC′s.

Qualität

Evaluated by Western Blot in 3T3/A31 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected IL-23 alpha in 10 µg of 3T3/A31 cell lysate.

Zielbeschreibung

UniProtKB/Swiss-Prot entry Q9NPF7 lists a molecular weight of 20.730 kDa In some lysates tested, non-specific bands are observed at around 40 kDa and around 55 kDa

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable