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05-858R

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Anti-Histone H4 Antibody, pan, clone 62-10C-2, rabbit monoclonal

clone 62-10C-2, from rabbit

Synonym(e):

H4, Histone H4, H4 histone family, member A, histone 1, H4a, histone cluster 1, H4a

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Antikörperform

culture supernatant

Antikörper-Produkttyp

primary antibodies

Klon

62-10C-2, monoclonal

Speziesreaktivität

human

Methode(n)

western blot: suitable

Isotyp

IgG

NCBI-Hinterlegungsnummer

NP_003529

UniProt-Hinterlegungsnummer

P62805

Versandbedingung

dry ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... H4C1(8359)

Allgemeine Beschreibung

Histone H4 is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H4 is involved with the structure of the nucleosomes of the ′beads on a string′ structure.

Spezifität

Broad species cross-reactivity expected based on 100% sequence homology to multiple species.

Immunogen

Epitope: Epitope mapped to residues 25-28.
KLH-conjugated, synthetic peptide corresponding to amino acids 17-28 of Histone H4.

Anwendung

Use Anti-Histone H4 Antibody, pan, clone 62-10C-2 (Rabbit Monoclonal Antibody) validated in WB to detect Histone H4 also known as Histone H4.

Qualität

Evaluated by Western Blot in HeLa acid extracts.

Western Blot Analysis: 0.1 µg/ml of this antibody detected histone H4 in 10 µg of HeLa cell lysate.

Zielbeschreibung

10 kDa Observed

Physikalische Form

Format: Purified
Purified Rabbit Monoclonal IgG Supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl), containing 40% glycerol with 0.05% sodium azide

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Manti Guha et al.
PloS one, 13(11), e0206897-e0206897 (2018-11-15)
Telomeres protect against chromosomal damage. Accelerated telomere loss has been associated with premature aging syndromes such as Werner's syndrome and Dyskeratosis Congenita, while, progressive telomere loss activates a DNA damage response leading to chromosomal instability, typically observed in cancer cells
Saravanan S Karuppagounder et al.
Science translational medicine, 8(328), 328ra29-328ra29 (2016-03-05)
Disability or death due to intracerebral hemorrhage (ICH) is attributed to blood lysis, liberation of iron, and consequent oxidative stress. Iron chelators bind to free iron and prevent neuronal death induced by oxidative stress and disability due to ICH, but
Benjamin E L Lauffer et al.
The Journal of biological chemistry, 288(37), 26926-26943 (2013-07-31)
Histone deacetylases (HDACs) are critical in the control of gene expression, and dysregulation of their activity has been implicated in a broad range of diseases, including cancer, cardiovascular, and neurological diseases. HDAC inhibitors (HDACi) employing different zinc chelating functionalities such

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