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Key Documents

05-832

Sigma-Aldrich

Anti-LKB1 Antibody, clone 5c10

clone 5c10, Upstate®, from mouse

Synonym(e):

Anti-LKB1, Anti-hLKB1

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

5c10, monoclonal

Speziesreaktivität

mouse, rat, human

Hersteller/Markenname

Upstate®

Methode(n)

immunocytochemistry: suitable
western blot: suitable

Isotyp

IgG

NCBI-Hinterlegungsnummer

NM_000455

UniProt-Hinterlegungsnummer

Q15831

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... STK11(6794)

Spezifität

Recognizes LKB1.

Immunogen

GST fusion protein corresponding to residues 1-433 of human LKB1

Anwendung

Research Category
Zelluläre Signaltransduktion
Research Sub Category
Insulin-/stoffwechselassoziierte Signalübertragung
This Anti-LKB1 Antibody, clone 5c10 is validated for use in IC, WB for the detection of LKB1.

Qualität

routinely evaluated by immunoblot on RIPA lysates from Rat2 cells

Zielbeschreibung

55 kDa

Physikalische Form

Protein G Purified
Format: Purified
Protein G Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl and 0.05% Sodium Azide, pH 7.4.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Control
Rat2 cell lysate

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Yuji Nakada et al.
PloS one, 8(9), e73449-e73449 (2013-10-03)
Germline mutations in the LKB1 gene (also known as STK11) cause the Peutz-Jeghers Syndrome, and somatic loss of LKB1 has emerged as causal event in a wide range of human malignancies, including melanoma, lung cancer, and cervical cancer. The LKB1
A F Baas et al.
The EMBO journal, 22(12), 3062-3072 (2003-06-14)
The LKB1 gene encodes a serine/threonine kinase mutated in Peutz-Jeghers cancer syndrome. Despite several proposed models for LKB1 function in development and in tumour suppression, the detailed molecular action of LKB1 remains undefined. Here, we report the identification and characterization
Molecular diagnosis and clinical relevance of t(9;22), t(4;11) and t(1 ;19) chromosome abnormalities in a consecutive group of 141 adult patients with acute lymphoblastic leukemia
Rambaldi, A., et al
Leukemia & Lymphoma, 21, 457-466 (1996)
Samantha M Behunin et al.
Archives of biochemistry and biophysics, 601, 32-41 (2016-03-15)
Contractile perturbations downstream of Ca(2+) binding to troponin C, the so-called sarcomere-controlled mechanisms, represent the earliest indicators of energy remodeling in the diseased heart [1]. Central to cellular energy "sensing" is the adenosine monophosphate-activated kinase (AMPK) pathway, which is known
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
Baas, A. F., et al
Cell, 116, 457-466 (2004)
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