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Merck

H-105

Supelco

17α-Hydroxypregnenolone solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirische Formel (Hill-System):
C21H32O3
CAS-Nummer:
Molekulargewicht:
332.48
UNSPSC-Code:
41116107
NACRES:
NA.24

Qualität

certified reference material

Qualitätsniveau

Form

liquid

Leistungsmerkmale

(Snap-N-Spike®)

Verpackung

ampule of 1 mL

Hersteller/Markenname

Cerilliant®

Konzentration

100 μg/mL in methanol

Methode(n)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Anwendung(en)

clinical testing
clinical testing

Format

single component solution

Lagertemp.

−20°C

InChI

1S/C21H32O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h4,15-18,23-24H,5-12H2,1-3H3/t15-,16+,17-,18-,19-,20-,21-/m0/s1

InChIKey

JERGUCIJOXJXHF-TVWVXWENSA-N

Allgemeine Beschreibung

17α-Hydroxypregnenolone is a steroid hormone produced in the adrenal glands. This hormone is monitored as an ancillary test for congenital adrenal hyperplasia (CAH), particularly in situations where diagnosis of 21-hydroxylase and 11-hydroxylase eficiency has been ruled out. This Certified Spiking Solution® is suitable for use as starting material in linearity standards, calibrators, and controls fo numerous LC-MS/MS applications in endocrinology, clinical chemistry, and neonatal screening.

Anwendung


  • Enhancement of Steroidogenic Enzyme Assays: The role of protein-protein and protein-membrane interactions in cytochrome P450 function, which is crucial for understanding the enzymatic activities involved in steroid biosynthesis, including those mediated by 17 alpha-Hydroxypregnenolone (Scott EE et al., 2016).

  • Modeling Steroid Hormone Biosynthesis: Research explores how ligand and cytochrome b5 modulate the conformation of human cytochrome P450 17A1, a key enzyme in the biosynthesis of neurosteroids from precursors like 17 alpha-Hydroxypregnenolone, providing insights for biochemical steroidogenesis research (Estrada DF et al., 2014).

  • Development of ELISA for Steroid Detection: The study demonstrate the covalent coupling of steroids to microwell plates, facilitating the use of 17 alpha-Hydroxypregnenolone in competitive enzyme-linked immunosorbent assays (ELISA) for steroid hormone precursor detection and quantification in biochemical assays (Yonezawa S et al., 1993).

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Zielorgane

Eyes

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 1

Flammpunkt (°F)

49.5 °F - closed cup

Flammpunkt (°C)

9.7 °C - closed cup


Analysenzertifikate (COA)

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

[17alpha-hydroxypregnenolone].
Yukiko Shimizu
Nihon rinsho. Japanese journal of clinical medicine, 63 Suppl 8, 340-343 (2005-09-10)

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