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C-059

Supelco

Clozapine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirische Formel (Hill-System):
C18H19ClN4
CAS-Nummer:
5786-21-0
Molekulargewicht:
326.82
EG-Nummer:
200-659-6
UNSPSC-Code:
41116107
NACRES:
NA.24

Qualität

certified reference material

Qualitätsniveau

300

Form

liquid

Leistungsmerkmale

SNAP-N-SPIKE®, SNAP-N-SHOOT®

Verpackung

ampule of 1 mL

Hersteller/Markenname

Cerilliant®

Konzentration

1.0 mg/mL in methanol

Methode(n)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Anwendung(en)

clinical testing

Format

single component solution

Lagertemp.

−20°C

SMILES String

CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24

InChI

1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3

InChIKey

QZUDBNBUXVUHMW-UHFFFAOYSA-N

Angaben zum Gen

human ... DRD2(1813) , HTR2A(3356)

Allgemeine Beschreibung

A Certified Snap-N-Spike® Solution for use in clinical toxicology, forensic analysis, or urine drug testing applications by LC/MS or GC/MS. Clozapine, sold as Clozaril® and FazaClo® in the US, is an atypical antipsychotic drug used for treatment of schizophrenia.

Anwendung



  • Augmentation Strategies for Clozapine Non-responders: A Bayesian network meta-analysis evaluated augmentation strategies for patients with schizophrenia who show partial or no response to clozapine, providing insights into effective secondary treatment options (Mishra et al., 2024).


  • Antipsychotic Pre-treatment and Clozapine Metabolism: Research highlighted the impact of rapid metabolism of antipsychotics prior to clozapine treatment, affecting serum levels and suggesting a need for adjusted dosing strategies in treatment-resistant schizophrenia (Lenk HÇ et al., 2024).


  • Genetic Influences on Clozapine Side Effects: A study identified polymorphisms in ERBB4 and TACR1 genes associated with dry mouth in patients treated with clozapine, pointing towards personalized management strategies for side effects (Puolakka et al., 2024).


  • Therapeutic Mechanisms of Antipsychotics: An analysis focused on understanding the therapeutic mechanisms of antipsychotics including clozapine, examining cellular and molecular targets and their implications for optimizing treatment efficacy in psychiatric disorders (Direktor et al., 2024).


  • Clozapine and Metabolic Syndrome in Schizophrenia: A study assessed the association between cytokine levels, psychopathology, and cognitive functions in clozapine-treated schizophrenia patients with metabolic syndrome, providing data critical for holistic treatment approaches (Dong et al., 2024).


Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Clozaril is a registered trademark of Sandoz, Inc.
FazaClo is a registered trademark of Jazz Pharmaceuticals International III Limited
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Zielorgane

Eyes,Central nervous system

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 2

Flammpunkt (°F)

49.5 °F - closed cup

Flammpunkt (°C)

9.7 °C - closed cup

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Chun-Hsin Chen et al.
The Journal of clinical psychiatry, 74(5), e424-e430 (2013-06-14)
Many studies have shown that metformin can decrease body weight and improve metabolic abnormalities in patients with schizophrenia. Whether or not the beneficial effects can be sustained after discontinuation of metformin needs to be evaluated. We conducted a 24-week randomized
Galvin Vredenburg et al.
Toxicology letters, 222(3), 247-256 (2013-08-07)
Clozapine, an often-prescribed antipsychotic drug, is implicated in severe adverse drug reactions (ADRs). Formation of reactive intermediates by cytochrome P450s (CYPs) has been proposed as a possible explanation for these ADRs. Moreover, a protective role for human glutathione S-transferases (hGSTs)
Shalini Jain et al.
The Journal of clinical investigation, 123(4), 1750-1762 (2013-03-13)
Type 2 diabetes (T2D) has emerged as a major threat to human health in most parts of the world. Therapeutic strategies aimed at improving pancreatic β cell function are predicted to prove beneficial for the treatment of T2D. In the
Chao-Cheng Lin et al.
Journal of clinical psychopharmacology, 33(2), 211-214 (2013-02-21)
Clozapine is the most effective antipsychotic for patients with treatment-refractory schizophrenia, but many adverse effects are noted. Clinicians usually hesitate to switch from clozapine to other antipsychotics because of the risk of a re-emergence or worsening of the psychosis, although
Bianca A Silva et al.
Nature neuroscience, 16(12), 1731-1733 (2013-11-12)
The neural circuits mediating fear to naturalistic threats are poorly understood. We found that functionally independent populations of neurons in the ventromedial hypothalamus (VMH), a region that has been implicated in feeding, sex and aggression, are essential for predator and
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