A-006

6-Acetylmorphin-d3 -Lösung

100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

• Synonym(e): 6-Acetylmorphin-N-methyl-d₃ -Lösung
• Empirische Formel (Hill-System): C₁₉D₃H₁₈NO₄
• CAS-Nummer: 136765-25-8
• Molekulargewicht: 330.39
• EG-Nummer: 200-835-2
• MDL-Nummer: MFCD00673257
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329770568
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material
• Qualitätsniveau: 300
• Form: liquid
• Leistungsmerkmale: SNAP-N-SPIKE^®. SNAP-N-SHOOT^®
• Verpackung: ampule of 1 mL
• Hersteller/Markenname: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
• Konzentration: 100 μg/mL in acetonitrile
• Methode(n): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Anwendung(en): forensics and toxicology
• Format: single component solution
• Massenverschiebung: M+3
• Lagertemp.: −20°C
• SMILES String: [2H]C([2H])([2H])N1CC[C@]23C4Oc5c(O)ccc(CC1C2C=C[C@@H]4OC(C)=O)c35
• InChI: 1S/C19H21NO4/c1-10(21)23-15-6-4-12-13-9-11-3-5-14(22)17-16(11)19(12,18(15)24-17)7-8-20(13)2/h3-6,12-13,15,18,22H,7-9H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1/i2D3
• InChIKey: JJGYGPZNTOPXGV-VALGNVEGSA-N

Beschreibung

Allgemeine Beschreibung

A stable-labeled internal standard suitable for quantitation of 6-acetylmorphine (6-MAM) levels in GC/MS or LC/MS testing for clinical toxicology, forensic analysis, urine drug testing, pain prescription monitoring and isotope dilution methods. Also known as 6-monoacetylmorphine, 6-MAM is an active metabolite of heroin and biomaker of heroin usage.

Anwendung

• Quantitative analysis of opiates in human fluids: A study employed 6-Acetylmorphine-d3 solution as part of a bioanalytical method using gas chromatography-triple quadrupole mass spectrometry for the precise quantification of opiates in human blood samples, highlighting its utility in forensic and clinical toxicology (Saad et al., 2019).


• Enhanced opioid metabolite detection: Research integrated 6-Acetylmorphine-d3 solution in an electrospray LC-MS method with solid-phase extraction, significantly improving the accuracy of detecting opioid metabolites in urine. This method is vital for drug monitoring and pharmacokinetic studies (Svensson et al., 2007).


• Forensic application in controlled drug programs: A study used 6-Acetylmorphine-d3 solution to establish dose-concentration relationships in hair from subjects in a controlled heroin-maintenance program, proving its essential role in forensic science for monitoring drug intake (Kintz et al., 1998).


• Drug monitoring in clinical settings: The solution was also applied in a novel assay for the determination of opioids in blood and pericardial fluid, offering a robust tool for clinical diagnostics and forensic investigations (Ferreira et al., 2020).

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS02,GHS07
• Signalwort: Danger
• H-Sätze: H225,H302 + H312 + H332,H319
• P-Sätze: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 2
• Flammpunkt (°F): 35.6 °F - closed cup
• Flammpunkt (°C): 2 °C - closed cup