890893P

GL67

Avanti Research^™ - A Croda Brand

• Synonym(e): N4-Cholesteryl-Spermine HCl salt
• Empirische Formel (Hill-System): C₃₈H₇₀N₄O₂· 3HCl
• CAS-Nummer: 179075-30-0
• Molekulargewicht: 724.37
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Form: powder
• Verpackung: pkg of 1 × 5 mg (890893P-5mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand
• Lipid-Typ: transfection; cationic lipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: CC1(CC[C@H](OC(N(CCCN)CCCCNCCCN)=O)C2)C2=CCC3C1CCC4(C)C3CCC4C(CCCC(C)C)C

Beschreibung

Allgemeine Beschreibung

N⁴-Cholesteryl-Spermine (GL67) comprises of the cationic lipid GL67 with spermine and cholesterol.

Anwendung

• GL67 lipid-based liposomal formulation for efficient siRNA delivery into human lung cancer cells.: This study explores the use of GL67 liposomes for delivering siRNA to human lung cancer cells, highlighting its potential for targeted cancer therapies (Jarallah et al., 2023).


• Aerosol-Mediated Non-Viral Lung Gene Therapy: The Potential of Aminoglycoside-Based Cationic Liposomes.: The research focuses on the efficacy of GL67 liposomes in aerosol form for non-viral gene therapy in the lungs, demonstrating significant gene transfer efficiency (Le Gall et al., 2021).


• Low-frequency ultrasound increases non-viral gene transfer to the mouse lung.: The study investigates the enhancement of GL67-mediated gene transfer using low-frequency ultrasound, showing improved transfection in mouse lungs (Xenariou et al., 2010).

Biochem./physiol. Wirkung

N⁴-Cholesteryl-Spermine (GL67) in combination with DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) and DMPE-PEG5000 (1,2-Dimyristoyl-sn-Glycero-3-Phosphoethanolamine-N-[methoxy (Polyethylene glycol)5000] is used as a non-viral gene transfer agent.

Verpackung

5 mL Amber Glass Screw Cap Vial (890893P-5mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): No data available
• Flammpunkt (°C): No data available