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880123P

Avanti

DSPE-PEG(5000) Folate

Avanti Research™ - A Croda Brand 880123P, powder

Synonym(e):

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000] (ammonium salt)

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About This Item

CAS-Nummer:
1236288-25-7
UNSPSC-Code:
12352211
NACRES:
NA.25

Form

powder

Verpackung

pkg of 1 × 500 μg (880123P-500ug)

Hersteller/Markenname

Avanti Research™ - A Croda Brand 880123P

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

[H][C@@](COP([O-])(OCCNC([(OCH2CH2)113]NC(CC[C@H](NC(C1=CC=C(NCC(C=N2)=NC3=C2N=C(N)NC3=O)C=C1)=O)C([O-])=O)=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+]

Allgemeine Beschreibung

DSPE-PEG(5000) Folate is a conjugate of folic acid and amino-PEG-DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol).

Biochem./physiol. Wirkung

Folate receptors are cellular surface markers for numerous solid tumors. DSPE-PEG-folate (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000]) incorporated into liposomes serves as a targeting ligand. Folate targeted drug delivery is useful in diagnosing and treating cancer and inflammatory diseases. Many molecules such as toxins (proteinaceous), immune stimulators and anti-cancer drugs can be delivered to folate receptor.

Verpackung

5 mL Amber Glass Screw Cap Vial (880123P-500ug)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery, 48-48 (2014)
Folate-targeted gadolinium-lipid-based nanoparticles as a bimodal contrast agent for tumor fluorescent and magnetic resonance imaging
Nakamura T, et al.
Biological & Pharmaceutical Bulletin, 37(4), 521-527 (2014)
Zhaoyan Yang et al.
ACS applied materials & interfaces, 11(51), 47671-47679 (2019-10-22)
Lead halide perovskite nanocrystals (NCs) are promising optical materials in many fields. However, their poor moisture stability, significant toxicity, and difficulty to be further functionalized greatly hinder their applications in bioimaging. Here, a universal strategy is demonstrated by simply encapsulating
Folate receptor-mediated drug targeting: from therapeutics to diagnostics
Hilgenbrink AR and Low PS
Journal of Pharmaceutical Sciences, 94(10), 2135-2146 (2005)
Tomonori Shiokawa et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 11(5), 2018-2025 (2005-03-10)
To establish a novel formulation tumor-targeted drug carrier of lipophilic antitumor antibiotics, aclacinomycin A (ACM), folate-linked microemulsions were prepared and investigated both in vitro and in vivo. Three kinds of folate-linked microemulsions with different polyethylene glycol (PEG) chain lengths loading
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