857125C

20:4 Lyso PA

1-arachidonoyl-2-hydroxy-sn-glycero-3-phosphate (ammonium salt), chloroform

• Synonym(e): arachidonoyl lysophosphatidic acid; 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate (ammonium salt); PA(20:4(5Z,8Z,11Z,14Z)/0:0); 20:4 LPA
• Empirische Formel (Hill-System): C₂₃H₄₂NO₇P
• CAS-Nummer: 799268-65-8
• Molekulargewicht: 475.56
• UNSPSC-Code: 51191904
• NACRES: NA.25

Eigenschaften

• Assay: >99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
• Form: liquid
• Verpackung: pkg of 1 × 1 mL (857125C-10mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand 857125C
• Konzentration: 10 mg/mL (857125C-10mg)
• Lipid-Typ: cardiolipins; phospholipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: O[C@](COP([O-])(O)=O)([H])COC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O.[NH4+]

Beschreibung

Allgemeine Beschreibung

Lysophosphatidic acid (LPA) is a lysophospholipid comprising of glycerol 3-phosphate (G3P), fatty acids, and phosphates.

Anwendung

20:4 Lyso PA (LPA) has been used in feeding low density lipoprotein receptor null (LDLR^-/-) mice. It is suitable for use as standard for high performance liquid chromatography (HPLC) and liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) for the quantification of human plasma LPA, and as a strong agonist for lysophosphatidic acid receptor1(LPA₁).

Biochem./physiol. Wirkung

Lysophosphatidic acid (LPA) is a bioactive lipid produced in tissues. LPA is involved in signal transduction through G-protein coupled receptors. LPA is implicated in many diseases including atherosclerosis, ischaemia perfusion injury, thrombosis and hypertension. LPA also plays an important role in wound healing processes, autoimmune diseases and tumor metastasis.

Verpackung

5 mL Clear Glass Sealed Ampule (857125C-10mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H302,H315,H319,H331,H336,H351,H361d,H372,H412
• P-Sätze: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Zielorgane: Central nervous system, Liver,Kidney
• Lagerklassenschlüssel: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): does not flash
• Flammpunkt (°C): does not flash