930709

Pomalidomide-piperazine-propanoic acid

≥95.0%

• Synonym(e): 1-Piperazinepropanoic acid, 3-(4-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)propanoic acid, 4-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]
• Empirische Formel (Hill-System): C₂₀H₂₂N₄O₆
• CAS-Nummer: 2591176-24-6
• Molekulargewicht: 414.41
• UNSPSC-Code: 12352106
• NACRES: NA.21

Eigenschaften

• ligand: pomalidomide
• Qualitätsniveau: 100
• Assay: ≥95.0%
• Form: powder
• Funktionelle Gruppe: carboxylic acid
• Lagertemp.: 2-8°C

Beschreibung

Anwendung

Pomalidomide-piperazine-propanoic acid is a functionalized Cereblon ligand used for development of pomalidomide-based degrader building blocks. Contains a terminal carboxyl group, allowing rapid conjugation of amine containing linkers. A basic building block for development of a protein degrader library.

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Sonstige Hinweise

Targeted Protein Degradation by Small Molecules


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Targeted Protein Degradation: from Chemical Biology to Drug Discovery


Impact of linker length on the activity of PROTACs

Rechtliche Hinweise

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable