Direkt zum Inhalt
Merck
Alle Fotos(1)

Dokumente

804371

Sigma-Aldrich

Fro-DO, mixture of diastereomers

97%

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

Empirische Formel (Hill-System):
C24H22N2O6S2
Molekulargewicht:
498.57
UNSPSC-Code:
12161600
PubChem Substanz-ID:
329768865
NACRES:
NA.22

Qualitätsniveau

100

Assay

97%

Form

powder

Eignung der Reaktion

core: nickel
reagent type: catalyst

SMILES String

O=C(N([C@H](C(C=CC=C1)=C1C2)[C@H]2C3)S3(=O)=O)/C=C/C(N4[C@H](C(C=CC=C5)=C5C6)[C@H]6CS4(=O)=O)=O

InChI

1S/C24H22N2O6S2/c27-21(25-23-17(13-33(25,29)30)11-15-5-1-3-7-19(15)23)9-10-22(28)26-24-18(14-34(26,31)32)12-16-6-2-4-8-20(16)24/h1-10,17-18,23-24H,11-14H2/b10-9+/t17-,18-,23+,24+/m1/s1

InChIKey

CZVFUQRTDAQUQL-SKLQJEMHSA-N

Anwendung

Enables the generation of quaternary centers by Ni-catalyzed cross coupling with aziridines.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Chung-Yang Dennis Huang et al.
Journal of the American Chemical Society, 137(17), 5638-5641 (2015-04-17)
A Ni-catalyzed Negishi cross-coupling with 1,1-disubstituted styrenyl aziridines has been developed. This method delivers valuable β-substituted phenethylamines via a challenging reductive elimination that affords a quaternary carbon. A novel electron-deficient olefin ligand, Fro-DO, proved crucial for achieving high rates and

Verwandter Inhalt

Doyle Group – Professor Product Portal

Research in the Doyle group focuses on two areas: nucleophilic fluorination and nickel catalysis. The Doyle group has developed several reagents that advance these research areas. In fluorination, 2-pyridinesulfonyl fluoride (PyFluor) can be used for the mild deoxyfluorination of primary and secondary alcohols, a procedure which is normally accomplished by the sensitive reagent DAST. In nickel catalysis, the Doyle group has developed a modular, air-stable nickel precatalyst, [(TMEDA)Ni(o-tolyl)Cl], which has broad utility for a wide variety of reactions. This precatalyst can be used in place of Ni(cod)2, NiCl2, as well as other reported precatalysts. Doyle has also reported electron-deficient olefin ligands as a new class of ligand for accelerated reductive elimination. In particular, the sultam-derived ligand Fro-DO has been found to be critical for high yields in the cross-coupling of tertiary aziridines to form quaternary centers.

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.