74540

Nordihydroguajaretsäure

≥97.0% (HPLC)

• Synonym(e): 1,4-Bis-(3,4-dihydroxyphenyl)-2,3-dimethyl-butan, 4,4′-(2,3-Dimethyltetramethylen)-dipyrocatechol, Masoprocol, NDGA
• Lineare Formel: [-CH(CH₃)CH₂C₆H₃-1,2-(OH)₂]₂
• CAS-Nummer: 500-38-9
• Molekulargewicht: 302.36
• Beilstein: 2056826
• EG-Nummer: 207-903-0
• MDL-Nummer: MFCD00002206
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 57652455
• NACRES: NA.22

Eigenschaften

• Assay: ≥97.0% (HPLC)
• Form: crystals
• Verunreinigungen: ≤2% water
• mp (Schmelzpunkt): 184-186 °C (lit.)
• SMILES String: CC(Cc1ccc(O)c(O)c1)C(C)Cc2ccc(O)c(O)c2
• InChI: 1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3
• InChIKey: HCZKYJDFEPMADG-UHFFFAOYSA-N
• Angaben zum Gen: mouse ... Alox12(11684)

Beschreibung

Allgemeine Beschreibung

Nordihydroguaiaretic acid (NDGA) is used as an antioxidant and potent scavenger of reactive oxygen species (ROS).

Anwendung

Nordihydroguaiaretic acid can be used:

• In the synthesis of nordihydroguaiaretic acid derivatives with potent HIV inhibition activity.
• As a starting material in the synthesis of tetra-O-methylnordihydroguaiaretic acid.

Biochem./physiol. Wirkung

Lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure.

Sonstige Hinweise

Inhibitor of broad bean lipoxygenase

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319,H335
• P-Sätze: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves