667005

(R)-(+)-3,3,3-Trifluor-1,2-Epoxypropan

97%

• Synonym(e): (R)-(+)-2-Trifluoromethyloxiran
• Empirische Formel (Hill-System): C₃H₃F₃O
• CAS-Nummer: 143142-90-9
• Molekulargewicht: 112.05
• MDL-Nummer: MFCD08276876
• UNSPSC-Code: 12352005
• PubChem Substanz-ID: 24884878
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 97%
• Brechungsindex: n20/D <1.300
• bp: 25-32 °C
• Dichte: 1.294 g/mL at 25 °C
• Funktionelle Gruppe: ether; fluoro
• Lagertemp.: 2-8°C
• SMILES String: FC(F)(F)[C@H]1CO1
• InChI: 1S/C3H3F3O/c4-3(5,6)2-1-7-2/h2H,1H2/t2-/m1/s1
• InChIKey: AQZRARFZZMGLHL-UWTATZPHSA-N

Beschreibung

Anwendung

(R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane can be used as a substrate to synthesize:

• Substituted trifluoro amino propanols, which are found to be potent inhibitors of cholesteryl ester transfer protein.
• (2R) Trifluoro-(methoxybenzyloxy)-propanol (chiral glycol) by reacting with 4-methoxybenzyl alcohol in the presence of NaH. Chiral glycol intermediate is further utilized for the preparation of trifluoromethyl glycol carbamates as potential monoacylglycerol lipase (MAGL) inhibitors.

Sicherheitshinweise

• Piktogramme: GHS02
• Signalwort: Danger
• H-Sätze: H224
• P-Sätze: P210 - P403 + P233
• Gefahreneinstufungen: Flam. Liq. 1
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 3
• Flammpunkt (°F): -14.8 °F
• Flammpunkt (°C): -26 °C
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves