556998
Phthalamsäure
97%
Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)
About This Item
Empfohlene Produkte
Qualitätsniveau
Assay
97%
Form
solid
mp (Schmelzpunkt)
140-143 °C (lit.)
Funktionelle Gruppe
amide
carboxylic acid
SMILES String
NC(=O)c1ccccc1C(O)=O
InChI
1S/C8H7NO3/c9-7(10)5-3-1-2-4-6(5)8(11)12/h1-4H,(H2,9,10)(H,11,12)
InChIKey
CYMRPDYINXWJFU-UHFFFAOYSA-N
Allgemeine Beschreibung
Phthalamic acid can be synthesized from the reaction between ammonia and phthalic anhydride by a modified Auger′s method. Kinetic studies of the intramolecular carboxylic-group assisted hydrolysis of amide bond of phthalamic acid provided the value of pseudo-first order rate constant (kobs) as 5.1×10-5sec-1 at pH 1.3-1.8 and 35°C. It undergoes hydrolysis about 105 times faster than benzamide.
Anwendung
Phthalamic acid may be used to synthesize anthranilic acid via reaction with sodium hypochlorite.
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Zielorgane
Respiratory system
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Gloves
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?General acid-base catalysis in the intramolecular hydrolysis of phthalamic acid1?
Journal of the American Chemical Society, 79(5), 1258-1259 (1957)
CCXXXVII.?The preparation of phthalamic acids and their conversion into anthranilic acids.
Journal of the Chemical Society, 127, 1791-1797 (1925)
Particle and fibre toxicology, 4, 8-8 (2007-09-22)
Pesticides, in particular folpet, have been found in rural and urban air in France in the past few years. Folpet is a contact fungicide and has been widely used for the past 50 years in vineyards in France. Slightly water-soluble
The hydrolysis and cyclization of some phthalamic acid derivatives.
Journal of the American Chemical Society, 88(19), 4468-4474 (1966-10-05)
Chirality, 29(6), 282-293 (2017-04-20)
Enantiomeric thalidomide undergoes various kinds of biotransformations including chiral inversion, hydrolysis, and enzymatic oxidation, which results in several metabolites, thereby adding to the complexity in the understanding of the nature of thalidomide. To decipher this complexity, we analyzed the multidimensional
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