536822
PAMAM-OH-Dendrimer, Generation 6 -Lösung
5 wt. % in methanol
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About This Item
Lineare Formel:
[NH2(CH2)2NH2]:(G=6);dendri PAMAM(NHCH2CH2OH)256
Molekulargewicht:
58298.21
MDL-Nummer:
UNSPSC-Code:
12162002
NACRES:
NA.25
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Beschreibung
amidoethanol surface groups
Qualitätsniveau
Form
liquid
Mol-Gew.
generation 6
Leistungsmerkmale
core type ethylenediamine core (2-carbon core)
Konzentration
5 wt. % in methanol
Anzahl Oberflächengruppen
256
Brechungsindex
n20/D 1.336
Dichte
0.807 g/mL at 25 °C
Lagertemp.
2-8°C
Allgemeine Beschreibung
PAMAM-OH (poly(amidoamine) dendrimers are highly branched core-shell nanostructures with surface hydroxyl groups. The presence of hydroxyl groups on the surface of the PAMAM-OH dendrimer molecule leads to stronger interaction with the components of the cell membrane via the formation of hydrogen bonds. This type of interaction can modify the properties and function of cell membranes. PAMAM-OH dendrimers also have an advantage over PAMAM dendrimers in terms of cytotoxicity and aggregation problems because of the absence of amine functionality.
Anwendung
PAMAM-OH dendrimer can be used to formulate poorly water-soluble drugs to increase water solubility, and therefore enhance the bioavailability of these drugs. It can also be applied to catalysts and organic molecules, where dendrimers function as solubility enhancers and modifiers.
Physikalische Form
Contains 256 surface hydroxyl groups.
Rechtliche Hinweise
Manufactured by Dendritech®, Inc.
Dendritech is a registered trademark of Dendritech, Inc.
Signalwort
Danger
H-Sätze
Gefahreneinstufungen
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Zielorgane
Eyes
Lagerklassenschlüssel
3 - Flammable liquids
WGK
WGK 3
Flammpunkt (°F)
51.8 °F - closed cup
Flammpunkt (°C)
11 °C - closed cup
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Comparative pharmacokinetics of PAMAM-OH dendrimers and HPMA copolymers in ovarian tumor-bearing mice
Sadekar S, et al.
Drug delivery and translational research, 3(3), 260-271 (2013)
The influence of PAMAM-OH dendrimers on the activity of human erythrocytes ATPases
Ciolkowski M, et al.
Biochimica et Biophysica Acta - Biomembranes, 1808(11), 2714-2723 (2011)
Polyplexes assembled with internally quaternized PAMAM-OH dendrimer and plasmid DNA have a neutral surface and gene delivery potency
Lee Jung Hoon, et al.
Bioconjugate Chemistry, 14(6), 1214-1221 (2003)
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