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Merck

378674

Sigma-Aldrich

Carbendazim

97%

Synonym(e):

BCM, Methyl-2-benzimidazolcarbamat, Methyl-benzimidazol-2-ylcarbamat

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About This Item

Empirische Formel (Hill-System):
C9H9N3O2
CAS-Nummer:
Molekulargewicht:
191.19
Beilstein:
649044
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352100
PubChem Substanz-ID:
NACRES:
NA.22

Qualitätsniveau

Assay

97%

Form

powder

mp (Schmelzpunkt)

>300 °C (lit.)

Löslichkeit

pyridine: soluble 1%, clear, very faintly brownish-yellow

SMILES String

COC(=O)Nc1nc2ccccc2[nH]1

InChI

1S/C9H9N3O2/c1-14-9(13)12-8-10-6-4-2-3-5-7(6)11-8/h2-5H,1H3,(H2,10,11,12,13)

InChIKey

TWFZGCMQGLPBSX-UHFFFAOYSA-N

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Allgemeine Beschreibung

Carbendazim is a systemic broad-spectrum fungicide, used worldwide against various fungal diseases of agricultural products. It is reported to pose deleterious effects on the human placental trophoblast cells. Dissipation pattern and risk assessment of carbendazim and mancozeb in mango fruits has been reported. The influence of carbendazim (methyl 2-benzimidazole carbamate) on the testis, efferent ductules and sperm of adult rat has been determined. Fast and sensitive method of determination of carbendazim (methyl benzimidazole-2-ylcarbamate, MBC) in water and soil samples has been developed by using dispersive liquid-liquid microextraction (DLLME) coupled with HPLC with fluorescence detection. Reaction kinetics of the transformation of the fungicide carbendazim induced by hydroxyl radical generated by the UV photolysis of H2O2 has been studied.

Anwendung

Carbendazim (Methyl 2-benzimidazolecarbamate, Methyl benzimidazol-2-ylcarbamate) has been used in the following studies:
  • As positive control in direct contact assay (mycelial radial growth inhibition assay).
  • As pesticide and its effect on the transcription responses of Enchytraeus albidus have been studied.
  • As broad-spectrum antifungal compound, to study the antibacterial action of anti-tuberculosis drugs against Mycobacterium tuberculosis in the Dubos broth culture medium.

Signalwort

Danger

Gefahreneinstufungen

Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 1B - Repr. 1B - Skin Sens. 1

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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1 of 6

M Nakai et al.
Journal of andrology, 13(6), 507-518 (1992-11-01)
The effects of carbendazim (methyl 2-benzimidazole carbamate) on the testis, efferent ductules, and sperm were determined in the adult rat after a single oral dose. Two experimental trials were performed: a time response between 2 hours and 32 days after
Jinghua Zhou et al.
Reproductive toxicology (Elmsford, N.Y.), 51, 64-71 (2014-12-23)
Benomyl and carbendazim are benzimidazole fungicides that are used throughout the world against a wide range of fungal diseases of agricultural products. There is as yet little information regarding the toxicity of benzimidazole fungicides to human placenta. In this study
David Coleman et al.
The Journal of antimicrobial chemotherapy, 66(1), 146-150 (2010-11-13)
to explore the effect of low incubation temperatures and the consequent slowing of bacterial metabolism on the bactericidal action of anti-tuberculosis drugs against Mycobacterium tuberculosis. counting of surviving bacteria during exposure of static cultures to 1 mg/L isoniazid, 2 mg/L
Gene expression responses linked to reproduction effect concentrations (EC10,20,50,90) of dimethoate, atrazine and carbendazim, in Enchytraeus albidus.
Novais SC, et al.
PLoS ONE, 7(4) (2012)
Degradation of carbendazim by UV/H2O2 investigated by kinetic modelling.
Mazellier P, et al.
Environmental Chemistry Letters, 1(1), 68-72 (2003)

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