373605

6,6′-Dithiodinikotinsäure

technical grade, 85%

• Synonym(e): Bis-[3-carboxypyridin]-6,6′-disulfid
• Empirische Formel (Hill-System): C₁₂H₈N₂O₄S₂
• CAS-Nummer: 15658-35-2
• Molekulargewicht: 308.33
• EG-Nummer: 239-729-6
• MDL-Nummer: MFCD00006454
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24863248
• NACRES: NA.22

Eigenschaften

• Qualität: technical grade
• Assay: 85%
• Form: solid
• mp (Schmelzpunkt): 263-265 °C (lit.)
• SMILES String: OC(=O)c1ccc(SSc2ccc(cn2)C(O)=O)nc1
• InChI: 1S/C12H8N2O4S2/c15-11(16)7-1-3-9(13-5-7)19-20-10-4-2-8(6-14-10)12(17)18/h1-6H,(H,15,16)(H,17,18)
• InChIKey: GSASOFRDSIKDSN-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

6,6′-Dithiodinicotinic acid is reported as sulphydryl reagent. 6,6′-Dithiodinicotinic acid is reported to react with thiols, to afford a disulfide and 6-mercaptonicotinic acid. Interaction of 6,6′-dithiodinicotinic acid with the homogenates of Ehrlich ascites cells has been reported.

Anwendung

6,6′-Dithiodinicotinic acid may be employed as:

• specific thiol blocker to investigate the radioprotective effect of mercaptoethylamine on the thiol level of the outer cell membrane of the Ehrlich ascites tumor cells
• modifier to investigate the polar microenvironment around the reactive Cys283 of rabbit muscle creatine kinase
• dipyridyl-dithio substrate to evaluate the protein disulfide-thiol interchange activity of the auxin stimulated NADH: protein disulfide reductase (NADH oxidase) of soybean plasma membranes
• water-soluble reagent in a study for introducing, in buffered saline, a reactive sulfhydryl group on water-soluble molecules bearing an alkyl-amino group
• chromogen for sulfhydryl groups in the Ellman method for cholinesterase determinations
• spectrophotometric determination of thiols and of total glutathione in human blood

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves