300764

1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indol

98%

• Synonym(e): Tetrahydronorharman, Tryptolin
• Empirische Formel (Hill-System): C₁₁H₁₂N₂
• CAS-Nummer: 16502-01-5
• Molekulargewicht: 172.23
• MDL-Nummer: MFCD00004954
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24857939
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 98%
• Form: liquid
• mp (Schmelzpunkt): 206-208 °C (lit.)
• SMILES String: C1Cc2c(CN1)[nH]c3ccccc23
• InChI: 1S/C11H12N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-4,12-13H,5-7H2
• InChIKey: CFTOTSJVQRFXOF-UHFFFAOYSA-N
• Angaben zum Gen: rat ... Htr2a(29595) , Htr2c(25187)

Beschreibung

Allgemeine Beschreibung

Ozonolysis of the enamine bond of 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole derivatives was studied.

Anwendung

Employed in alkaloid synthesis and in studies on neurodegenerative diseases.

• Reactant for synthesis of the indolyl-β-carboline alkaloid eudistomin U via IBX mediated room temperature oxidative aromatization
• Reactant for preparation of neuroprotective HDAC6 inhibitors
• Reactant for preparation of aminofuranopyrimidines as EGFR and Aurora A kinase inhibitors
• Reactant for preparation of inhibitors of CDK4
• Reactant for preparation of tetrahydrocarboline derivatives of as human 5-HT5A receptor ligands
• Reactant for preparation of 5-(diaminomethyl)-2,4-aminopyrimidines as dihydrofolate reductase inhibitors and antibacterial agents

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves