263443

1-Brom-2,4-difluorbenzol

98%

• Lineare Formel: BrC₆H₃F₂
• CAS-Nummer: 348-57-2
• Molekulargewicht: 192.99
• Beilstein: 1680892
• EG-Nummer: 206-479-4
• MDL-Nummer: MFCD00000330
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24855973
• NACRES: NA.22

Eigenschaften

• Assay: 98%
• Brechungsindex: n20/D 1.505 (lit.)
• bp: 145-146 °C (lit.)
• mp (Schmelzpunkt): −4 °C (lit.)
• Dichte: 1.708 g/mL at 25 °C (lit.)
• Funktionelle Gruppe: bromo; fluoro
• SMILES String: Fc1ccc(Br)c(F)c1
• InChI: 1S/C6H3BrF2/c7-5-2-1-4(8)3-6(5)9/h1-3H
• InChIKey: MGHBDQZXPCTTIH-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

1-Bromo-2,4-difluorobenzene undergoes lithiation exclusively at the position having two adjacent halogen substituents, to yield 6-bromo-2,3-difluorobenzoic acid.

Anwendung

1-Bromo-2,4-difluorobenzene has been used in:

• preparation of (2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-sila-ethoxy)-propan-1-one
• enantiomeric preparation of the key intermediate of chiral azole antifungal agents by a chemoenzymatic process

Sicherheitshinweise

• Piktogramme: GHS02,GHS07
• Signalwort: Warning
• H-Sätze: H226,H315,H319,H335
• P-Sätze: P210 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 3
• Flammpunkt (°F): 125.6 °F - closed cup
• Flammpunkt (°C): 52 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter