222569

Fomepizol

99%

• Synonym(e): 4-Methyl-pyrazol
• Empirische Formel (Hill-System): C₄H₆N₂
• CAS-Nummer: 7554-65-6
• Molekulargewicht: 82.10
• Beilstein: 105204
• EG-Nummer: 231-445-0
• MDL-Nummer: MFCD00005245
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24853343
• NACRES: NA.22

Eigenschaften

• Assay: 99%
• Brechungsindex: n20/D 1.495 (lit.)
• bp: 99-100 °C/6 mmHg (lit.)
• Löslichkeit: alcohol: soluble(lit.); water: soluble(lit.)
• Dichte: 0.993 g/mL at 25 °C (lit.)
• SMILES String: Cc1cn[nH]c1
• InChI: 1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
• InChIKey: RIKMMFOAQPJVMX-UHFFFAOYSA-N
• Angaben zum Gen: human ... ADH1A(124) , ADH1B(125) , ADH1C(126)

Beschreibung

Allgemeine Beschreibung

4-Methylpyrazole inhibits CYP2E1 activity. It also acts as alcohol dehydrogenase inhibitor.

Anwendung

Fomepizole (4-Methylpyrazole) can be used as:

• A reactant to prepare 4-methyl-1-phenyl-1H-pyrazole by reacting with bromobenzene via N-arylation using a copper catalyst.
• A starting material for the synthesis of 4-methyl-3(5)-nitropyrazole by nitration.
• A ligand in the preparation of gallium(III) complex of 4-methylpyrazole as potential antitumor and antiviral agent.

Gegengift bei Methanol- und Ethylenglykolvergiftungen

Biochem./physiol. Wirkung

Alcohol dehydrogenase inhibitor

Alcohol dehydrogenase inhibitor.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302 - H315 - H319 - H335
• P-Sätze: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): 204.8 °F - closed cup
• Flammpunkt (°C): 96 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter