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SRP2080

Sigma-Aldrich

BRCA1 human

recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

Sinónimos:

BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PSCP, RNF53

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.26

biological source

human

recombinant

expressed in insect cells

assay

≥70% (SDS-PAGE)

form

frozen liquid

mol wt

~209 kDa

packaging

pkg of 20 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

350 μg/mL

color

clear
 colorless

NCBI accession no.

NM_007296

UniProt accession no.

P38398

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... BRCA1(672)

Biochem/physiol Actions

The human BRCA1, the product of breast and ovarian cancer gene 1, is a hyperphosphorylated protein functioning as a tumor suppressor involved in both transcription regulation and DNA repair. BRCA1 associates with RAD51 and has shown to be required for transcription-coupled repair of DNA damage as well as for the repair of chromosomal double-strand breaks. Association with a human SWI/SNF-related complex has recently suggested a potential role of BRCA1 in linking chromatin remodeling to breast cancer.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Corinne Chabalier-Taste et al.
Oncotarget, 7(3), 2269-2283 (2016-01-09)
Accurate repair of DNA double-strand breaks (DSB) caused during DNA replication and by exogenous stresses is critical for the maintenance of genomic integrity. There is growing evidence that the Polo-like kinase 1 (Plk1) that plays a number of pivotal roles
E Maldonado et al.
Nature, 381(6577), 86-89 (1996-05-02)
We report here the isolation of a human RNA polymerase II complex containing a subset of the basal transcription factors and the human homologues of the yeast SRB (for suppressors of RNA polymerase B) proteins. The complex contains transcriptional coactivators
R Scully et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(11), 5605-5610 (1997-05-27)
The familial breast-ovarian tumor suppressor gene product BRCA1 was found to be a component of the RNA polymerase II holoenzyme by several criteria. BRCA1 was found to copurify with the holoenzyme over multiple chromatographic steps. Other tested transcription activators that
S K Sharan et al.
Nature, 386(6627), 804-810 (1997-04-24)
Inherited mutations in the human BRCA2 gene cause about half of the cases of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair

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