SML1784

BTI-A-404

≥98% (HPLC)

• Sinónimos: 4-[4-(Dimethylamino)phenyl]-N-(3,5-dimethylphenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxamide
• Fórmula empírica (notación de Hill): C₂₂H₂₆N₄O₂
• Número de CAS: 537679-57-5
• Peso molecular: 378.47
• UNSPSC Code: 51111800
• PubChem Substance ID: 329826063
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: O=C1NC(C2=CC=C(N(C)C)C=C2)C(C(NC3=CC(C)=CC(C)=C3)=O)=C(C)N1
• InChI key: JQVNMIXFWKEYQJ-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

BTI-A-404 is a potent and selective competitive inverse agonist of human GPR43 (FFAR2).

BTI-A-404 is a potent and selective competitive inverse agonist of human GPR43 (GPR43/Free Fatty Acid Receptor 2, FFAR2) that increases the cyclic AMP level and regulates and reduces acetate-induced cytoplasmic Ca²⁺ level. BTI-A-404 regulates the downstream signaling pathways of GPR43, including ERK, p38 MAPK, and NF-KB. BTI-A-404 stimulates GLP-1 release.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable