MAK327
Aldehyde Dehydrogenase Inhibitor Screening Kit
sufficient for 100 colorimetric tests
Sinónimos:
ALDH Inhibitor Assay Kit
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
Productos recomendados
usage
sufficient for 100 colorimetric tests
detection method
colorimetric
relevant disease(s)
cancer
storage temp.
−20°C
Categorías relacionadas
General description
Aldehyde Dehydrogenases (ALDHs) are a superfamily of oxidoreductases which catalyze the conversion of aldehydes to carboxylic acids. ALDH is crucial in the metabolism of alcohol as alcohol dehydrogenase breaks down ethanol to acetaldehyde. Acetaldehyde, which is toxic to the body, is in turn broken down by ALDH to acetic acid. Imbalances of aldehyde dehydrogenase have been linked to both alcoholism and alcohol sensitivity in people. Inhibitors of the enzyme have been used in cases to treat alcoholism in patients. Cancer stem cell populations also display a heightened activity of ALDH, making ALDH inhibition a promising anti-cancer therapy approach.
Application
The Aldehyde Dehydrogenase Inhibitor Screening Kit may be used for:
- Alcohol Metabolism Research
- Cancer Research
- Drug Discovery
Features and Benefits
- High-Throughput Compatibility: The kit seamlessly integrates into high-throughput handling systems, ensuring efficiency and accuracy.
- Efficient Inhibitor Screening: Screen for ALDH inhibitors with as little as 5 µL of test compound, facilitated by a streamlined procedure requiring minimal effort.
Suitability
Suitable for inhibitor screening and evaluation of ALDH inhibitors.
Principle
The Aldehyde Dehydrogenase Inhibitor Screening Kit is based on the enzymatic conversion of acetaldehyde to acetic acid and NADH by ALDH. The formed NADH in turn reduces a formazan reagent into a colored product the absorbance of which, measured at 565 nm, is proportional to the enzyme activity in the reaction. The percent inhibition of a test compound can be determined by comparing the activity of ALDH treated with a test compound to the activity of untreated ALDH.
Other Notes
For additional information on our range of Biochemicals, please complete this form.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B
Storage Class
3 - Flammable liquids
wgk_germany
WGK 2
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico