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Key Documents

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L4420

Sigma-Aldrich

LY-367385 hydrochloride

≥98% (HPLC)

Sinónimos:

(S)-(+)-a-amino-4-carboxy-2-methylbenzeneacetic acid

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About This Item

Fórmula empírica (notación de Hill):
C10H11NO4 ·HCl
Número de CAS:
198419-91-9
Peso molecular:
245.66
MDL number:
MFCD02262124
UNSPSC Code:
12352200
PubChem Substance ID:
329817409
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

H2O: >10 mg/mL

originator

Eli Lilly

storage temp.

room temp

SMILES string

Cc1cc(ccc1[C@H](N)C(O)=O)C(O)=O

InChI

1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1

InChI key

SGIKDIUCJAUSRD-QMMMGPOBSA-N

Application

LY-367385 hydrochloride has been used as a non-N-methyl-D-aspartate (NMDA) glutamate receptor blocker in neuronal stimulation experiment.

Biochem/physiol Actions

LY-367385 hydrochloride has an ability to inhibit induction of long-term potentiation (LTP).
LY-367385 is a selective metabotropic glutamate 1a receptor (mGlu1a) antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Synaptic activity induces input-specific rearrangements in a targeted synaptic protein interaction network
Lautz JD, et al.
Journal of Neurochemistry, 146(5), 540-559 (2018)
Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons
Bonsi P, et al.
Neuropharmacology, 49(5), 104-113 (2005)
D Y Sakae et al.
Molecular psychiatry, 20(11), 1448-1459 (2015-08-05)
Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are centrally involved in reward behavior. TANs express a vesicular glutamate transporter referred to as VGLUT3 and thus use both acetylcholine and glutamate as neurotransmitters. The respective roles of each
Miseon Kang et al.
Scientific reports, 10(1), 17921-17921 (2020-10-23)
Abnormally increased neuronal activity in the lateral habenula (LHb) is closely associated with depressive-like behavior. Despite the emphasis on the pathological importance of NMDA receptor (NMDAR)-dependent long-term depression (LTD) and the involvement of calcium permeable AMPA receptor (CP-AMPAR) as major
Hanne Mette Hoffmann et al.
The international journal of neuropsychopharmacology, 20(1), 72-82 (2016-10-17)
Cocaine addiction continues to be a major heath concern, and despite public health intervention there is a lack of efficient pharmacological treatment options. A newly identified potential target are the group I metabotropic glutamate receptors, with allosteric modulators showing particular
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