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Merck

KCQS02

Sigma-Aldrich

KiCqStart® SYBR® Green qPCR ReadyMix

with ROX for ABI instruments

Sinónimos:

qPCR master mix, sybr green qPCR

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About This Item

UNSPSC Code:
41106300
NACRES:
NA.55

form

liquid

usage

sufficient for 1250 reactions
sufficient for 250 reactions
sufficient for 5000 reactions

feature

dNTPs included
hotstart

storage condition

protect from light

technique(s)

qPCR: suitable

color

colorless

input

purified DNA

compatibility

for use with ABI 5700
for use with ABI 7000
for use with ABI 7300
for use with ABI 7700
for use with ABI 7900 HT Fast
for use with ABI 7900 HT
for use with ABI 7900
for use with ABI StepOne
for use with ABI StepOnePlus

detection method

SYBR® Green

shipped in

dry ice

storage temp.

−20°C

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General description

KiCqStart SYBR Green qPCR ReadyMix es una mezcla maestra lista para usar concentrado X2 que contiene todos los componentes, excepto los cebadores y la plantilla, para la PCR cuantitativa (qPCR) en tiempo real Esta combinación única de tampón patentado, estabilizadores y ADN polimerasa Taq de inicio en caliente proporciona la eficiencia, sensibilidad y especificidad máximas de la PCR y una señal fluorescente robusta cuando se utilizan protocolos de ciclado rápidos o convencionales con SYBR Green qPCR.

Es crucial una amplificación muy específica para conseguir una qPCR satisfactoria con tecnología de colorante SYBR Green I porque este colorante se une a, y detecta, cualquier dsDNA generado durante la amplificación. La ADN polimerasa Taq de inicio en caliente es inactivada por anticuerpo antes de la etapa inicial de desnaturalización de la PCR.

Application

KiCqStart® SYBRSYB® Green qPCR ReadyMix has been used:

  • in the amplification and quantification of cDNA reverse transcribed from RNA extracted from mice brain samples in a 2-step RT-qPCR assay
  • to analyze DNA purified by ChIP technique
  • to perform gene expression analysis
  • in amplification of RNA isolated from hearts of adult TL wild-type fish by quantitative real-time polymerase chain reaction (PCR)
Aplicaciones de la PCR:
  • Expresión génica
  • Cuantificación del ADN
  • CHiP

Features and Benefits

  • Resultados del análisis en tan sólo 33 minutos
  • Resultados de la PCR en tiempo real muy eficaces y sensibles
  • Se requiere poca o ninguna optimización

Components

2X reaction buffer containing optimized concentrations of MgCl2, dNTPs, (dATP, dCTP, dGTP, dTTP), KiCqStart Taq DNA Polymerase, SYBR Green dye, ROX Reference Dye (for 580-585 nm excitation), and stabilizers.

packaging:
250 reactions* = 2 X 1.25 mL tubes
1250 reactions* = 10 X 1.25 mL tubes
5000 reactions* = 1 X 50 mL tube
*number of reactions based on a 20uL volume

Other Notes

Condiciones de conservación:
La mezcla KiCqStart SYBR Green qPCR ReadyMix es estable durante 1 año cuando se conserva en un refrigerador a una temperatura constante de -20°C, protegida de la luz. Para su conveniencia, puede conservarse sin congelar entre +2 y +8°C durante un máximo de 6 meses. Después de descongelar, mezcle bien antes de usar. No se recomienda congelar y descongelar repetidamente el producto. Sin embargo, se demostró que el producto no perdía rendimiento después de 20 ciclos de congelación-descongelación o 2 meses a +20°C.

Legal Information

Applied Biosystems is a registered trademark of Applera Corporation or its subsidiaries in the US and/or certain other countries
KiCqStart is a registered trademark of QIAGEN Beverly Inc.
ROX is a trademark of Applera Corporation or its subsidiaries in the US and/or certain other countries
ReadyMix is a trademark of Sigma-Aldrich Co. LLC
SYBR is a registered trademark of Life Technologies
StepOne is a trademark of Applera Corporation or its subsidiaries in the US and/or certain other countries
StepOnePlus is a trademark of Applera Corporation or its subsidiaries in the US and/or certain other countries

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Gene expression study of phase I and II metabolizing enzymes in RPTEC/TERT1 cell line: application in in vitro nephrotoxicity prediction.
Shah H
Xenobiotica, 3, 1-7 (2016)
Gene expression study of phase I and II metabolizing enzymes in RPTEC/TERT1 cell line: application in in vitro nephrotoxicity prediction
<BIG><BIG>Shah H, et al.</BIG></BIG>
Xenobiotica, 47, 837-843 (2017)
Aneesh K Ramaswamy et al.
Matrix biology plus, 4, 100014-100014 (2019-09-04)
Elastogenesis within the medial layer of the aortic wall involves a cascade of events orchestrated primarily by smooth muscle cells, including transcription of elastin and a cadre of elastin chaperone matricellular proteins, deposition and cross-linking of tropoelastin coacervates, and maturation
Eoghan M Cunnane et al.
Bioengineering (Basel, Switzerland), 8(5) (2021-05-01)
Macromolecular components of the vascular extracellular matrix (ECM), particularly elastic fibers and collagen fibers, are critical for the proper physiological function of arteries. When the unique biomechanical combination of these fibers is disrupted, or in the ultimate extreme where fibers
The functional and inflammatory response of brain endothelial cells to toll-like receptor agonists
Johnson RH, et al.
Scientific Reports, 8, 1-12 (2018)

Artículos

After a traditional PCR has been completed, the PCR/qPCR data analysis is conducted by resolution through an agarose gel or, more recently, through a capillary.

PCR assay guide navigates you through primer validation and other assay optimization factors to ensure high sensitivity and specificity for optimum DNA/ RNA quantification.

Protocolos

Quantitative PCR protocol using SYBR Green reagents. Procedure supports most qPCR instruments.

Gradient PCR for assay optimization is to determine the optimum annealing temperature (Ta) of the primers by testing identical reactions containing a fixed primer concentration, across a range of annealing temperatures.

Measuring a target quantity relative to one or more stable reference genes using SYBR Green I dye detection is a common application of qPCR. Below is a standard protocol that can be adapted to specific experimental needs.

Once an assay has been optimized, it is important to verify the reaction efficiency. This information is important when reporting and comparing assays. In this example protocol, the assay efficiency is compared over a wide and narrow dynamic range of cDNA concentrations.

Ver todo

Contenido relacionado

SYBR® Green I, a commonly used fluorescent DNA binding dye, binds all double-stranded DNA and detection is monitored by measuring the increase in fluorescence throughout the cycle. Explore our LuminoCt® and KiCqStart® products for Fast qPCR or JumpStart™ reagents for conventional qPCR

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