K0253
Keratin from human epidermis
aqueous solution
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About This Item
Productos recomendados
biological source
human epidermis
assay
≥90% (SDS-PAGE)
form
urea solution
technique(s)
ELISA: suitable
UniProt accession no.
storage temp.
2-8°C
Gene Information
human ... KRT1(3848)
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General description
Keratins are characteristic intermediate filament proteins of the epithelia. In human, keratin is classified into type I and type II. About 54 genes encodes for the keratin protein. The keratin 1 (KRT1) gene is mapped to human chromosome 12q13.13. It is the primary component of hair, skin and nails.
Application
Keratin from human epidermis has been used:
- as an analyte and a cross-reactant in the antibody-immobilized chip for testing selectivity coefficients
- as a standard in extracellular matrix (ECM) protein in in vitro protein degradation assays.
- asa a standard in enzyme linked immunosorbent assay (ELISA)
Biochem/physiol Actions
Keratins are important for the mechanical stability and integrity of epithelial cells and tissues. Some keratins also have regulatory functions and are involved in intracellular signaling pathways, e.g. protection from stress, wound healing, and apoptosis. This diverse group of cytoskeletal scaffolding proteins form intermediate filament networks which provide structural support to keratinocytes that maintain the integrity of the skin. Expression of keratin genes is usually regulated by differentiation of the epidermal cells within the stratifying squamous epithelium.
Physical form
Solution in 8 M urea, 50 mM Tris, 0.1 M β-mercaptoethanol and 0.1% sodium azide, pH 8.4
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Los clientes también vieron
Cornelia Kröger et al.
The Journal of cell biology, 201(5), 681-692 (2013-05-22)
Maintenance of epithelial cell adhesion is crucial for epidermal morphogenesis and homeostasis and relies predominantly on the interaction of keratins with desmosomes. Although the importance of desmosomes to epidermal coherence and keratin organization is well established, the significance of keratins
Keratin-based Biomaterials and Bioproducts, 5-5 (2017)
[Sinonasal neoplasms].
Zhan-bo Wang et al.
Zhonghua bing li xue za zhi = Chinese journal of pathology, 42(1), 50-51 (2013-04-25)
Comparison of biomarkers in exhaled breath condensate and bronchoalveolar lavage
Jackson AS, et al.
American Journal of Respiratory and Critical Care Medicine, 175(3), 222-227 (2007)
Christian Mozet et al.
Anticancer research, 33(6), 2415-2424 (2013-06-12)
The hedgehog signaling pathway (HH) is involved in tumorigenesis in a variety of human malignancies. In head and neck squamous cell carcinomas (HNSCC), Hh overexpression was associated with poor prognosis. Therefore, we analyzed the effect of Hh signaling blockade with
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