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D4921

Sigma-Aldrich

Destruxin A from Metarrhizium anisopliae

≥98% (HPLC)

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About This Item

Fórmula empírica (notación de Hill):
C29H47N5O7
Número de CAS:
6686-70-0
Peso molecular:
577.71
MDL number:
MFCD01736100
UNSPSC Code:
12352200
PubChem Substance ID:
329798802
NACRES:
NA.32

biological source

Metarrhizium anisopliae

Quality Level

200

assay

≥98% (HPLC)

form

powder

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CC=C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O

InChI

1S/C29H47N5O7/c1-9-12-21-27(38)34-16-11-13-20(34)26(37)31-23(18(5)10-2)28(39)33(8)24(17(3)4)29(40)32(7)19(6)25(36)30-15-14-22(35)41-21/h9,17-21,23-24H,1,10-16H2,2-8H3,(H,30,36)(H,31,37)/t18-,19-,20+,21-,23-,24-/m0/s1

InChI key

XIYSEKITPHTMJT-UTJJDKHZSA-N

Application

Destruxin A from Metarrhizium anisopliae has been used for immersion and inoculation bioassay in Rhipicephalus (Boophilus) microplus. It has been used as a transport inhibitor in Drosophila melanogaster.

Biochem/physiol Actions

Destruxin A is a cyclic hexadepsipeptide produced by fungus causing paralysis and death in insects. May suppress the insect immune response. Possesses an inhibitory activity on leukemic cell proliferation, decreasing the number of cells in G2/M phase. It is virustatic against arboviruses.

Quality

Balance is other destruxins

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
14181003
067M4099V
14160611
083M4152V
14130407

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Chengshu Wang et al.
FEMS microbiology letters, 226(2), 373-378 (2003-10-14)
In a previous study, a spontaneous subtilisin pr1A and pr1B gene-deficient mutant of the entomopathogenic fungus Metarhizium anisopliae strain V275 has been identified [Wang, C.-S. et al. (2002) FEMS Microbiol. Lett. 213, 251-255]. The insecticidal metabolites of this mutant were
K Sowjanya Sree et al.
Pest management science, 64(2), 119-125 (2007-10-16)
The cyclodepsipeptide destruxin produced by the entomopathogen Metarhizium anisopliae (Metch.) was administered by different methods, topical application, ingestion and a combination of the two, in an attempt to minimize the mycotoxin dose for efficient management of the insect pest Spodoptera
Maria Hinaje et al.
Archives of biochemistry and biophysics, 405(1), 73-77 (2002-08-15)
Destruxin A, a cyclohexadepsipeptide related to the enniatins and beauvericin, exhibits ionophoric properties. Calcium ion mobilization across liposomal membrane barriers, for example, has been demonstrated using the calcium ion-sensitive dyes Arsenazo III and Fura-2. Initial molecular mechanics/molecular dynamics calculations indicate
K Sowjanya Sree et al.
Toxicon : official journal of the International Society on Toxinology, 51(7), 1140-1150 (2008-03-15)
The cyclodepsipeptidic mycotoxin, destruxin, produced by Metarhizium anisopliae is known for its larvicidal properties. The crude destruxin-treated Spodoptera litura larvae revealed a decrease in thiol content and an increment in oxidation of glutathione to glutathione disulfide and ascorbate to dehydro
M Soledade C Pedras et al.
Phytochemistry, 59(6), 579-596 (2002-02-28)
Destruxins, secondary metabolites first reported in 1961, are cyclic hexadepsipeptides composed of an alpha-hydroxy acid and five amino acid residues. The name "destruxin" is derived from "destructor" from the species Oospora destructor, the entomopathogenic fungus from which these metabolites were
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