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Documentos

PHR1207

Supelco

2-Butanona

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Etilmetilcetona, MEK, Metiletilcetona

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About This Item

Fórmula lineal:
C2H5COCH3
Número de CAS:
78-93-3
Peso molecular:
72.11
Beilstein/REAXYS Number:
741880
EC Number:
201-159-0
MDL number:
MFCD00011648
UNSPSC Code:
41116107
PubChem Substance ID:
329823214
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to USP 1430101

vapor density

2.49 (vs air)

vapor pressure

71 mmHg ( 20 °C)

CofA

current certificate can be downloaded

autoignition temp.

960 °F

expl. lim.

10.1 %

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.379 (lit.)

bp

80 °C (lit.)

mp

−87 °C (lit.)

density

0.805 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CC(CC)=O

InChI

1S/C4H8O/c1-3-4(2)5/h3H2,1-2H3

InChI key

ZWEHNKRNPOVVGH-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. 2-Butanone (Methyl ethyl ketone, MEK), an aliphatic ketone, is considered as an aprotic and protophilic solvent. Its ability as an anticonvulsive agent in lithium-pilocarpine-induced status epilepticus in rats is reported.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0146 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system

supp_hazards

EUH066

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

30.2 °F - closed cup

flash_point_c

-1 °C - closed cup

Choose from one of the most recent versions:

Certificados de análisis (COA)

Lot/Batch Number
LRAC9786
LRAC0146
P500207
LRAB3828

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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2-Butanona suitable for HPLC, ≥99.7%

Sigma-Aldrich

34861

2-Butanona

Terc-butilmetil éter Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1560

Terc-butilmetil éter

Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition (2012)
Yang Cao et al.
British journal of haematology, 168(5), 701-707 (2014-11-06)
CXCR4(WHIM) frameshift and nonsense mutations follow MYD88(L265P) as the most common somatic variants in Waldenström Macroglobulinaemia (WM), and impact clinical presentation and ibrutinib response. While the nonsense (CXCR4(S338X) ) mutation has been investigated, little is known about CXCR4 frameshift (CXCR4(FS)
Federico Mele et al.
Nature communications, 6, 6431-6431 (2015-03-17)
T helper (TH) cell polarization during priming is modulated by a number of signals, but whether polarization to a given phenotype also influences recall responses of memory TH cells is relatively unknown. Here we show that miR-181a is selectively induced
Inna V Fedorenko et al.
Proteomics, 15(2-3), 327-339 (2014-10-24)
Basal and kinase inhibitor driven adaptive signaling has been examined in a panel of melanoma cell lines using phosphoproteomics in conjunction with pathway analysis. A considerable divergence in the spectrum of tyrosine-phosphorylated peptides was noted at the cell line level.
L Schafranek et al.
Leukemia, 29(1), 76-85 (2014-05-13)
Kinase inhibitors block proliferative signals in BCR-ABL1+ leukemic cells, but their capacity to induce apoptosis is poorly understood. Initial studies suggested that very brief exposure to kinase inhibitors was sufficient to induce apoptosis in chronic myeloid leukemia (CML) cells. However
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